L-Arginine Supplementation and Exercise; L-Arginine Supplementation and Renal Function
Phase 4
Completed
- Conditions
- Heart Transplantation
- Registration Number
- NCT00213915
- Lead Sponsor
- University Hospital, Strasbourg, France
- Brief Summary
* exercise capacities are still altered after heart transplantation partly due to peripheral endothelial dysfunction
* cyclosporin-induced renal dysfunction may be due to renal endothelial dysfunction and can be reversed in an animal model by L-arginine supplementation
* to determine the potential beneficial effect of L-arginine supplementation on exercise capacity and renal function of heart transplant recipients
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
- Male (> 18 years old) stable heart transplant recipient for at least 6 weeks
- Stable treatment for at least 3 months
- Sedentary people
Exclusion Criteria
- Unstable cardiac pathology
- Obesity (IMC > 40)
- Participation in another study in the last month
- Chronic renal failure (creatinine clearance < 20 ml/min)
- Renal transplantation
- Diabetes
- Impossibility to practice exercise test
- Nitrate therapy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Maximal and sub maximal exercise capacity at the end of the 6 weeks L-arginine supplementation. Renal function at the end of the 6 weeks
- Secondary Outcome Measures
Name Time Method No secondary effects
Trial Locations
- Locations (3)
Service de Chirurgie Vasculaire
🇫🇷Strasbourg, France
Service des Explorations Fonctionnelles Respiratoires et de l'Exercice
🇫🇷Strasbourg, France
Institut de Physiologie
🇫🇷Strasbourg, France