Evaluation of the Prognostic Value of T7 and T12 Slices on Mortality in Resuscitation Patients With ARDS Caused by SARS-COV2 Infection

Not yet recruiting

• Conditions: Acute Respiratory Distress Syndrom (SARS-Cov 2)
• Interventions: Other: Data collection; Other: analysis of thoracic scans

• Registration Number: NCT05594550
• Lead Sponsor: Centre Hospitalier Universitaire Dijon

Brief Summary

Sarcopenia is a risk factor for adverse outcome in critically ill patients. Sarcopenia might be estimated from muscle surface measure on tomodensitometry.

The purpose of the study is to identify if muscle surfaces measured on thoracic tomodensitometry are associated with mortality in patients with acute respiratory distress syndrome due to SARS-Cov-2.

Detailed Description

Not available

Study Timeline

• Status Verified: 2022-10
• Study Start: 2022-10
• Study First Submitted: 2022-10-21
• Study First Submitted QC: 2022-10-21
• Last Update Submitted: 2022-10-21
• Study First Posted: 2022-10-26
• Last Update Posted: 2022-10-26
• Primary Completion: 2022-12
• Study Completion: 2022-12

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• patients hospitalized in intensive care for SARS-Cov-2 infection since january 2020
• Thoracic TDM within the 30 day preceding ICU admission and up to 24 hours after ICU admission

Exclusion Criteria

• Pregnancy
• Neuromuscular disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
28-day death	analysis of thoracic scans	Deceased 28 days after intensive care admission
28-day survival	analysis of thoracic scans	Alive 28 days after intensive care admission
28-day death	Data collection	Deceased 28 days after intensive care admission
28-day survival	Data collection	Alive 28 days after intensive care admission

Primary Outcome Measures

Name	Time	Method
measurement of muscle area at T7 level indexed in cm²/m².	At hospital admission	use of CT measurements to discriminate between the 2 groups (deceased versus alive)

Secondary Outcome Measures

Name	Time	Method
number of days in Intensive care unit	within the 28 days
Duration of mechanical ventilation	within the 28 days
Ventilator free days	within the 28 days
number of days in hospital	within the 28 days