Observational Study on Serum Calcium and Serum Lactate Ratio in Acute Pancreatitis for predicting Severity, Clinical outcome and Hospital stay duration at KLES Prabhakar Kore Hospital.

Not yet recruiting

Conditions: Acute pancreatitis, unspecified,

Registration Number: CTRI/2023/09/057952

Lead Sponsor: KLES Prabhakar Kore Hospital

Brief Summary: Primary Purpose of Study

-Early detection of severity of acute pancreatitis with help of markers Serum Calcium and Serum Lactate, which can be readily available in laboratories, which is not time consuming and does not require experts to interpret the values/reports.

- Categorizing acute pancreatitis into mild, moderate and severe using this ratio. Early detection of severe acute pancreatitis is important so as to deliver proper aggressive care to patient and to avoid its complications.

-Early intervention. Better prognosis and reduced hospital stay duration when intervened early.

Study Hypothesis:

Hypocalcemia is consistent with severe acute pancreatitis and Lactate is a product of anaerobic metabolism of glucose and is generally considered to be a marker of tissue hypoxia. In addition, previous studies have also found that the presence of elevated arterial lactate levels reflects critical tissue hypoperfusion, which is strongly associated with increased morbidity and mortality in critically ill patients. A recent study has shown that elevated serum lactate is a new biomarker that could be an important tool in predicting poor outcomes of Acute Pancreatitis on admission, especially in predicting death. Thus, we assume that arterial lactate may be an important biomarker to stratify patients with Acute Pancreatitis. Hence, serum calcium and serum lactate (in mmol/L) can be useful to predict severity of cases early in disease onset as hypocalcaemia is found to be a poor prognostic marker and elevated lactate level is a marker of sepsis, tissue hypoxia and necrosis. Moreover much literature on serum calcium: serum lactate ratio levels have not been found.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 49

Inclusion Criteria

Patients willing to give consent, of either sex, of age group 21-60 years and diagnosed as acute pancreatitis.
The diagnosis of Acute Pancreatitis should include two of the following three features: 1.Upper Abdominal pain of acute onset often radiating to back.
2.Serum amylase or lipase activity greater than 3 times normal, and 3.
findings on cross sectional abdominal imaging consistent with acute pancreatitis.

Exclusion Criteria

Age< 21 years, 2.
Pregnant and lactating females, 3.
Patients in sepsis due to any other cause other than acute pancreatitis ruled out by detailed history and clinical examination.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
serum Calcium and Serum Lactate Ratio	At baseline (on admission) and on discharge

Secondary Outcome Measures

Name	Time	Method
ICU stay duration and complications	After admission and management during the course of hospitalisation

Trial Locations

Locations (1): KLES DR.PRABHAKAR KORE HOSPITAL
🇮🇳
Belgaum, KARNATAKA, India
KLES DR.PRABHAKAR KORE HOSPITAL
🇮🇳Belgaum, KARNATAKA, India
DrEkta Bharadia
Principal investigator
8247339679
b.ekta888@gmail.com