Usefulness of Serum Procalcitonin for Predicting Serious Bacterial Infection in Febrile Infants Less Than 3 Months
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 2,209
- 试验地点
- 1
- 主要终点
- Area under the ROC curve of the serum Procalcitonin concentration in the diagnosis of serious bacterial infections
研究概览
简要总结
The primary objective is to study the value of serum procalcitonin as a predictive marker for severe bacterial infection in febrile infants.
2200 febrile infants aged less than 3 months will prospectively be included. All infants will have a measure of Procalcitonin concentrations. Comparison of the mean value of Procalcitonin concentration in infants with and without serious Bacterial infection.
Evaluation of the area under the ROC for Procalcitonin concentration.
详细描述
Serious bacterial infections are often difficult to detect in infant with fever without source. Procalcitonin is a better blood marker of infection than White blood cell count and possibly than C-reactive protein. This could lead to a reduction in antibiotic prescription. Our objective is to evaluate the impact of Procalcitonin result on antibiotic prescription in children 1 to 3 month old with fever without source and our hypothesis is that it will lower the antibiotic prescription rate.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 7 Days 至 3 Months（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Infant older than 7 days old and less than 3 months old.
- •Fever (defined by a rectal temperature greater than or equal to 38°C)
- •Emergency consultation
排除标准
- •Infants with a previously identified immunodeficiency or chronic disease,
- •Antibiotic treatment within the previous 48 hours
结局指标
主要结局
Area under the ROC curve of the serum Procalcitonin concentration in the diagnosis of serious bacterial infections
时间窗: At the day of emergency consultation for fever
次要结局
- Diagnostic value (sensibility and specificity) of clinical examination versus procalcitonin(At the day of emergency consultation for fever)
- Diagnostic value (sensibility and specificity) of complete blood count versus procalcitonin(At the day of emergency consultation for fever)
- Diagnostic value (sensibility and specificity) of CRP versus procalcitonin(At the day of emergency consultation for fever)