How Does Your Genetic Make-up (Profile) Influence Your Glaucoma?
- Conditions
- Primary Open Angle Glaucoma
- Registration Number
- NCT00626847
- Lead Sponsor
- Wills Eye
- Brief Summary
Glaucoma is a group of diseases in which visual loss occurs because of damage to the optic nerve. Research has shown that certain genes may cause glaucoma in some cases. So far, research has only been able to find the genes responsible for glaucoma in a small percentage of people who have glaucoma. The purpose of this project is to study the genes in patients with and without glaucoma to find additional genes that may be responsible for causing glaucoma.
- Detailed Description
Four tubes of blood will be taken from 100 people. Of those, half will have primary open angle glaucoma (POAG) and the other half will be controls (normals), half will be caucasians and the other half will be african americans, half male and half female. All groups will have a routine ophthalmic eye exam, color vision, snellen vision, and visual field done.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 97
- 40 yrs
- Caucasian or African American
- Male or female with POAG, PACG, PXFG,
- Normal
- Other ophthamic co-morbidities
- Other ethnic groups
- Unable to understand and give informed consent
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The investigators will quantify the spectrum of changes in mitochondrial respiration, relative mitochondrial DNA content, and oxidative stress associated with different types of glaucoma. one blood draw
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Wills Eye Glaucoma Service
🇺🇸Philadelphia, Pennsylvania, United States