a 3.0T Magnetic Resonance Imaging Study

• Conditions: Primary Open Angle Glaucoma

• Registration Number: NCT01346904
• Lead Sponsor: Huazhong University of Science and Technology

Brief Summary

Glaucomatous damage not only occurred to retinal ganglion cells in the eyes, but went across optic nerves, visual chiasm, lateral geniculate nucleus (LGN) and finally the visual cortex; the neural degenerations could be identified through the whole visual tract, which suggests the central nerve system may play a vital role in the progression of glaucoma. The investigators used MRI to investigate changes of visual pathway in vivo.

Detailed Description

Not available

Study Timeline

• Status Verified: 2011-05
• Study Start: 2011-05
• Study First Submitted: 2011-05-02
• Study First Submitted QC: 2011-05-02
• Last Update Submitted: 2011-05-02
• Study First Posted: 2011-05-03
• Last Update Posted: 2011-05-03
• Primary Completion: 2012-12
• Study Completion: 2012-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• Primary open angle glaucoma diagnosed on the basis of glaucomatous optic disc cupping ratio (in particular, thinning of the inferior and/or superior rim, cup-to-disc ratio asymmetry of >0.2)
• matching glaucomatous visual field defects (European Glaucoma Society (2008) Perimetry )

Exclusion Criteria

• optic neuropathy
• neurological disorder
• other diseases and use of systemic medications which affect optic nerve or the visual field underwent complete eye examination and visual-field testing.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified