The effect of propofol-fentanyl compared with sevoflurane-fentanyl on the incidence of postoperative nausea vomiting after infratentorial craniotomy: A randomized controlled trial

Phase 4

Recruiting

Conditions: Patient who undergoes infratentorial craniotomy
Infratentorial craniotomy
Postoperative nausea vomiting
Intravenous anesthesia
Inhalation anesthesia

Registration Number: TCTR20211013004

Lead Sponsor: Faculty of Medicine, Chulalongkorn university

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 62

Inclusion Criteria

1. Patient who undergoes infratentorial craniotomy
2. The American Society of Anesthesiologists (ASA) Physical Status Classification I-III
3. Expected to extubate after surgery

Exclusion Criteria

1. Patient who refuse to be included in the project.
2. Anesthesia without surgery.
3. Patient who receive combined intravenous anesthesia and inhaled anesthesia.
4. Patient with increased intracranial pressure.
5. Patient with abnormal liver function or chronic alcoholism.
6. Patient who is suspected for malignant hyperthermia
7. Patient with opioid allergy.
8. Patient who receive antiemetic prophylaxis within 24 hours before surgery.
9. Patient with history of chemotherapy within 4 weeks before surgery or radiation within 8 weeks before surgery.
10. Patient who remain intubated after surgery

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Postoperative nausea/vomitting 24 hours postoperatively PONV scoring

Secondary Outcome Measures

Name	Time	Method
Postoperative nausea/vomitting 0, 0.5,1,2,6,12,48 hours postoperatively PONV scoring,Brain relaxation before dura opening and during surgery Brain relaxation score assessed by surgeon,Antiemetic medication 48 hours post operative Total amount of antiemetic medication patient received,Mean blood pressure, heart rate baseline, intubation, dural opening, every hour during surgery, dural closure, extubation Mean blood pressure, heart rate,Medication for hemodynamic control during the surgery Amount of norepinephrine, labeterol , esmolol,Anesthesia and Surgical time during the operation Time of anesthesia and Surgery,Time to follow command, time to eye opening, time to extubation After stopping the anesthetic agent time after the cessation of the anesthetic agent to time when patient follow command, open their eyes and extubatne