Comparison of prophylactic administration of cefazolin, ampicillin and azithromycin in prevention of postpartum infections after cesarea

Phase 2

• Conditions: postpartum infection.; Complications predominantly related to the puerperium; 085-092

• Registration Number: IRCT2013080710511N2
• Lead Sponsor: Arak University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: Female
• Target Recruitment: 375

Inclusion Criteria

Inclusion criteria were:
Non-elective Caesarean section women candidates; Gestational age of 28 weeks and more.

Exclusion criteria were:
Sensitivity to cefazolin or ampicillin or azithromycin; Unwillingness of patients; Received systemic antibiotics within 2 last weeks; Fever prior cesarean; PROM more than 18 hours; chorioamnionitis; Receiving immunosuppressive drugs; Diseases such as diabetes and immune deficiency: liver disease, kidney disease and heart failure or pulmonary edema; multiple pregnancies; preeclampsia; Urinary tract infection or pneumonia; Operation for more than an hour; Intraoperative subcutaneous drains; Abnormal adherence of the placenta to be observed during operation; Elective caesarean; Diarrhea at the time of delivery; Any patient with significant electrolyte disturbances such as hypokalemia, hypocalcemia.

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Postpartum infection. Timepoint: Discharge, 2 weeks and 6 weeks after surgery. Method of measurement: Fever, abdominal pain, uterine tenderness, erythema, and purulent discharge from the wound.

Secondary Outcome Measures

Name	Time	Method
Duration of hospitalization. Timepoint: Study duration. Method of measurement: Medical record.