Can Resistance Enhance Selection of Treatment? (CREST)

Not Applicable

Completed

• Conditions: HIV Infection

• Registration Number: NCT00262717
• Lead Sponsor: Kirby Institute

Brief Summary

To compare two commercially available platforms for assessment of HIV drug resistance to determine which provides superior virological results.

We hypothesise that one test will be significantly superior to the other.

Detailed Description

Not available

Study Timeline

• Study Start: 2001-03-01
• Study First Submitted: 2005-12-06
• Study First Submitted QC: 2005-12-06
• Study First Posted: 2005-12-07
• Primary Completion: 2006-01-30
• Study Completion: 2006-07-31
• Status Verified: 2025-06
• Last Update Submitted: 2025-06-23
• Last Update Posted: 2025-06-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 338

Inclusion Criteria

• HIV infected patients taking combination antiretroviral therapy, with plasma HIV RNA> 2000copies/mL, who were willing to change ARVs and who provided informed consent.

Exclusion Criteria

• Patients who were ARV naïve, who were experiencing an acute illness or judged to be unable to comply with the protocol requirements.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
The comparison between randomly assigned study arms in the mean area under the curve plasma HIV RNA at 48 weeks.	at 48 weeks follow-up

Secondary Outcome Measures

Name	Time	Method
Proportion of patients with undetectable plasma HIV RNA, Changes in CD4+ cell count, use of resistance test result in selecting new ART regimen	at 48 weeks

Trial Locations

Locations (19)

Interchange General Practice; 🇦🇺 Canberra, Australian Capital Territory, Australia

Royal Prince Alfred Hospital; 🇦🇺 Camperdown, New South Wales, Australia

Sydney Sexual Health Clinic; 🇦🇺 Sydney, New South Wales, Australia

AIDS Research Initiative; 🇦🇺 Sydney, New South Wales, Australia

Albion Street Centre; 🇦🇺 Sydney, New South Wales, Australia

Holdsworth House General Practice; 🇦🇺 Sydney, New South Wales, Australia

St. Vincent's Hospital; 🇦🇺 Sydney, New South Wales, Australia

Taylor Square Private Clinic; 🇦🇺 Sydney, New South Wales, Australia

Prince of Wales Hospital; 🇦🇺 Sydney, New South Wales, Australia

Livingston Road Sexual Health; 🇦🇺 Sydney, New South Wales, Australia

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