Can Resistance Enhance Selection of Treatment? (CREST)
- Conditions
- HIV Infection
- Registration Number
- NCT00262717
- Lead Sponsor
- Kirby Institute
- Brief Summary
To compare two commercially available platforms for assessment of HIV drug resistance to determine which provides superior virological results.
We hypothesise that one test will be significantly superior to the other.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 300
- HIV infected patients taking combination antiretroviral therapy, with plasma HIV RNA> 2000copies/mL, who were willing to change ARVs and who provided informed consent.
- Patients who were ARV naïve, who were experiencing an acute illness or judged to be unable to comply with the protocol requirements.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method The comparison between randomly assigned study arms in the mean area under the curve plasma HIV RNA at 48 weeks.
- Secondary Outcome Measures
Name Time Method Proportion of patients with undetectable plasma HIV RNA, Changes in CD4+ cell count, use of resistance test result in selecting new ART regimen
Trial Locations
- Locations (19)
Sydney Sexual Health Clinic
🇦🇺Sydney, New South Wales, Australia
Holdsworth House General Practice
🇦🇺Sydney, New South Wales, Australia
Prince of Wales Hospital
🇦🇺Sydney, New South Wales, Australia
Interchange General Practice
🇦🇺Canberra, Australian Capital Territory, Australia
Royal Prince Alfred Hospital
🇦🇺Camperdown, New South Wales, Australia
St. Vincent's Hospital
🇦🇺Sydney, New South Wales, Australia
Cairns Base Hospital
🇦🇺Cairns, Queensland, Australia
Albion Street Centre
🇦🇺Sydney, New South Wales, Australia
QLD Health - AIDS Medical Unit
🇦🇺Brisbane, Queensland, Australia
AIDS Research Initiative
🇦🇺Sydney, New South Wales, Australia
Gold Coast Sexual Health Clinic
🇦🇺Miami, Queensland, Australia
Alfred Hospital
🇦🇺Melbourne, Victoria, Australia
Royal Perth Hospital
🇦🇺Perth, Western Australia, Australia
Prahran Market Clinic
🇦🇺Melbourne, Victoria, Australia
Melbourne Sexual Health Centre
🇦🇺Melbourne, Victoria, Australia
Fremantle Hospital
🇦🇺Fremantle, Western Australia, Australia
Livingston Road Sexual Health
🇦🇺Sydney, New South Wales, Australia
Taylor Square Private Clinic
🇦🇺Sydney, New South Wales, Australia
Care and Prevention Programme
🇦🇺Adelaide, South Australia, Australia