Perioperative Database of Chinese Elderly Patients for Postoperative Acute Kidney Injury
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 57,089
- 主要终点
- Number of participants with postoperative acute kidney injury
研究概览
简要总结
To develop and externally validate a risk prediction model for postoperative acute kidney injury (PO-AKI) in elderly patients undergoing major noncardiac surgery, addressing the current gap in predictive tools for this vulnerable population.
The endpoint was the occurrence of PO-AKI within seven days following surgery. Diagnoses were based on the Kidney Disease: Improving Global Outcomes (KDIGO) criterion. Potential PO-AKI-related perioperative data were retrieved and extracted from electronic medical record for model derivation and validation.
Clinicians may consider implementing this externally validated risk prediction model to stratify elderly patients' PO-AKI risks in the early postoperative phases of noncardiac surgery in elderly patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 65 Years 至 120 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •elderly patients (aged ≥ 65 years) undergoing non-cardiac surgeries
排除标准
- •(1) Patients who underwent endoscopic or transplant procedures;
- •(2) Patients who underwent surgeries lasting longer than 10 hours;
- •(3) Patients who had severe preoperative kidney dysfunction, defined as preoperative sCr levels ≥ 353.6 μmol/L, or a baseline estimated Glomerular Filtration Rate (eGFR) < 15 ml/min per 1.73 m2;
- •(4) Patients without sCr values at baseline or during follow-up to detect PO-AKI occurrences.
结局指标
主要结局
Number of participants with postoperative acute kidney injury
时间窗: within seven days following surgery
Postoperative acute kidney injury
次要结局
未报告次要终点
研究者
Weidong Mi
Director (Cheif expert of National key research and development program of China 2018YFC2001900)
Chinese PLA General Hospital