Predictive Nomogram for Postoperative Acute Kidney Injury in Older Patients Undergoing Noncardiac Surgery
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Postoperative Acute Kidney Injury
- Sponsor
- Chinese PLA General Hospital
- Enrollment
- 50000
- Locations
- 1
- Primary Endpoint
- acute kidney injury
- Last Updated
- 3 years ago
Overview
Brief Summary
Postoperative acute kidney injury is associated increased risk of morbidity and mortality. Older patients are at high risk of developing postoperative acute kidney injury. However, the incidence and associations of postoperative acute kidney injury in older patients are not well understood. This study aims to develop and validate a predictive nomogram for postoperative acute kidney injury in older patients undergoing noncardiac surgery.
Detailed Description
Postoperative acute kidney injury (AKI) affects approximately 2% to 40% of patients undergoing cardiac and major noncardiac surgeries. Older patients are more susceptible to renal impairment than younger patients. However, the incidence and associations of AKI in older patients are rarely understood. Generally, in-depth knowledge of risk factors and thus able to identify patients at high risk to develop postoperative AKI is essential to optimize perioperative prevention and protection strategies. In this retrospective study, the investigators intend to develop and validate a predictive model for postoperative using the identified risk factors. The primary outcome is postoperative AKI, which according to the Kidney Disease: Improving Global Outcomes (KDIGO) criterion, is defined as an absolute increase in serum creatinine of 0.3 mg/dL within 48 hours or a 1.5-fold increase from preoperative baseline within 7 days after surgery.
Investigators
Weidong Mi
Director (Cheif expert of National key research and development program of China 2018YFC2001900)
Chinese PLA General Hospital
Eligibility Criteria
Inclusion Criteria
- •Patients aged 65 years and older
Exclusion Criteria
- •Emergency operation
- •Cardiac surgery
- •Incomplete data
- •Incomplete data
- •Local anesthesia
- •Preoperative renal failure or requirement for dialysis
Outcomes
Primary Outcomes
acute kidney injury
Time Frame: 7 days after surgery
an absolute increase in serum creatinine of 0.3 mg/dl within 48 hours or a 1.5-fold increase from preoperative baseline within 7 days after surgery