Risk Factors for Acute Kidney Injury in Patients Undergoing Arthroplasty

Completed

• Conditions: Arthroplasty; Postoperative Acute Kidney Injury

• Registration Number: NCT06296108
• Lead Sponsor: Ankara University

Brief Summary

The authors aimed to determine the risk factors associated with postoperative acute kidney injury in patients undergoing total joint arthroplasty.

Detailed Description

Aim: The primary aim of the current study is to determine the risk factors associated with postoperative acute kidney injury in patients undergoing total joint arthroplasty. Considering that this patient group is mostly composed of advanced age and comorbid patients, the secondary aim of the study is to identify risky patients with predictable risk factors and to chart a way to make preoperative optimizations of the patients before developing postoperative complications.

Materials and Methods: Patients who underwent joint arthroplasty between 2015 and 2020 in Ankara University Faculty of Medicine, Department of Orthopedics and Traumatology were included. Within the scope of the study, patients' gender, age, weight, height, body mass index values, smoking, American Society of Anesthesiologist (ASA) score, Charlson-Comorbidity Index score (CCI), type of operation, duration of surgery, presence of intraoperative hypotension, anesthesia method , diabetes, hypertension, coronary artery disease, presence of congestive heart failure, presence of preoperative anemia, preoperative uric acid and albumin level, use of nephrotoxic agents in the perioperative period, basal creatinine and glomerular filtration rate (GFR) values, platelet suspension in the perioperative period, erythrocyte suspension, Amounts of fresh frozen plasma transfusions, postoperative creatinine at 24 hours - 48 hours - discharge, GFR values and Kidney Disesae Improving Global Outcomes (KDIGO) scores, length of hospital stay and length of stay in the intensive care unit were evaluated.

Study Timeline

• Study Start: 2022-06-01
• Primary Completion: 2022-12-31
• Study Completion: 2022-12-31
• Study First Submitted: 2024-02-26
• Status Verified: 2024-03
• Study First Submitted QC: 2024-03-04
• Last Update Submitted: 2024-03-04
• Study First Posted: 2024-03-06
• Last Update Posted: 2024-03-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 911

Inclusion Criteria

• Patients aged above 18 years old undergoing arthroplasty surgery

Exclusion Criteria

• Known acute renal failure or chronic renal failure
• Patients aged below 18 years old
• Patients refusing to participate to the study

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Acute kidney injury in patients undergoing arthroplasty surgery	Retrospective between 2015-2020	To determine the incidence of acute kidney injury in patients undergoing arthroplasty surgery

Secondary Outcome Measures

Name	Time	Method
Risk factors causing acute kidney injury in patients undergoing arthroplasty surgery	Retrospective between 2015-2020	To determine the risk factors causing acute kidney injury in patients undergoing arthroplasty surgery

Trial Locations

Locations (1)

Ankara University Medical School Anesthesiology and ICU Department; 🇹🇷 Ankara, Turkey