Favorable and unfavorable effects of risk-reducing salpingo-oophorectomy (RRSO) in women at high genetic risk of ovarian cancer
- Conditions
- BotgezondheidovariectomyRRSO1007446910003216
- Registration Number
- NL-OMON50443
- Lead Sponsor
- Antoni van Leeuwenhoek Ziekenhuis
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 750
Female patients
High genetic risk of ovarian cancer
Risk reducing salpingo-oophorectomy before the age of 46, or (for control
group):
High genetic risk for ovarian cancer
Natural menopause after age of 50 years
No RRSO before 55 years of age
No treatment induced menopause before 50 years of age
For both groups:
History of gynecological cancer at time of RRSO
History of cancer at time of testing for BRCA-1 / BRCA-2
Ovariectomy for other reasons in patient history
Cystectomy in patients history
Metastatic disease
Other serious comorbidity, psychiatric disorders, which would interfere with a
clinic visit
Not enough understanding of the Dutch language
Non-bioresorbable cardiac stent
Younger age than 55 years
Premature Ovarian Insufficiency
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method