Comparative Clinical Trials of Laser Photobiomodulation and Platelets Rich in Growth Factors (PRGFs)-Assisted Flap Surgery in Treating Stage III Periodontal Defects: an In-Depth Analysis of Clinical Outcomes and Healing Processes
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 20
- 主要终点
- -Evaluation of the changes in the clinical attachment loss
研究概览
简要总结
Stage 3 periodontitis is a condition marked by swift and severe destruction of periodontal tissues. To effectively regenerate osseous defects resulting from periodontal disease, it is crucial to leverage the intrinsic regenerative potential of the periodontium via meticulously formulated therapeutic strategies
详细描述
The main treatment methods of periodontal diseases involve scaling and root planning (SRP), and periodontal surgery. Periodontopathogens, can penetrate deep by crossing the epithelial barrier which may be difficult to be remove by nonsurgical periodontal therapy (NSPT) alone. A multitude of grafted and non-grafted approaches have been used in the management of Intra-bony defects. However, they do not provide predictable periodontal regeneration.
A systematic review on the use of platelet-rich fibrin (PRF) for managing periodontal defects highlights its promising potential in periodontal regeneration. It forms a fibrin matrix that promotes angiogenesis and enhances healing at defected sites. The review emphasizes PRF's ability to sustain the release of growth factors, which are crucial for osteoblastic proliferation, migration, and adherence. This makes PRF an effective scaffold for cellular elements, facilitating periodontal tissue regeneration.
Laser photobiomodulation (PBM) has emerged as a promising adjunctive treatment as it stimulates cellular processes, enhancing the natural regenerative capabilities of periodontal tissues. Recent studies have demonstrated that PBM, particularly with diode, significantly improves clinical outcomes when combined with conventional periodontal treatments. It promotes osteoblastic proliferation, migration, and adherence, thereby facilitating bone regeneration and reducing periodontal pocket depth. Additionally, PBM enhances angiogenesis and modulates the release of growth factors, creating an optimal healing environment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients with PPD =5 mm and clinical attachment loss of ≥3 mm;
- •Presence of 2 walled or 3 walled infra-bony defects posterior segments;
- •Evidence of ≥3 mm of intra-bony defect depth evaluated by the visualization of peri-apical radiographs.
排除标准
- •Patients requiring antibiotic prophylaxis before the periodontal examination;
- •Patients diagnosed with malocclusion at the site of the defect;
- •Patients with systemic disease and/or on drugs that contraindicate periodontal surgery;
- •Patients with a history of smoking and pan chewing;
- •Sites with advanced class II & III furcation involvement.
结局指标
主要结局
-Evaluation of the changes in the clinical attachment loss
时间窗: [Time Frame: at base line, 1 month and 3 months after treatment]
Attachment level will be measured using UNC15(University of North Carolina) periodontal probe. Clinical attachment loss will be measured as the distance from the cemento-enamel junction to the base of the pocket.\[Time Frame: at base line, 1 month and 3 months after treatment\]
probing depth
时间窗: [Time Frame: at base line, 1 month and 3 months after treatment]
The measurement will be recorded by UNC15(University of North Carolina) periodontal probe . Pocket depth will be measured as the distances from the free gingival margin to the base of the periodontal pocket.
次要结局
- -Plaque index (PI)([Time Frame: at base line, 1 month and 3 months after treatment])
- Gingival index (GI)([Time Frame: at base line, 1 month and 3 months after treatment])
研究者
Nashwa Helaly Mohamed
lecturer
Assiut University