Antimicrobial Photodynamic Therapy in Treatment of Aggressive Periodontitis (Stage III, Grade C Periodontitis)

Not Applicable

Completed

• Conditions: Aggressive Periodontitis
• Interventions: Device: antimicrobial photodynamic therapy; Drug: systemic antibiotics

• Registration Number: NCT05655338
• Lead Sponsor: University of Ljubljana

Brief Summary

Treatment of aggressive periodontitis (stage III, grade C periodontitis) represents a big challenge. The aim of the study was to compare the long-term results of antimicrobial photodynamic therapy (aPDT) and antibiotic therapy as an adjunct to conventional non-surgical therapy in patients with aggressive periodontitis. Clinical parameters of probing depth, clinical attachment level and bleeding on probing (BOP) were assessed at baseline, 3, 6, 9 and 12 months after treatment.

Detailed Description

Background: Treatment of aggressive periodontitis (stage III, grade C periodontitis) represents a big challenge. The aim of the study was to compare the long-term results of antimicrobial photodynamic therapy (aPDT) and antibiotic therapy as an adjunct to conventional non-surgical therapy in patients with aggressive periodontitis. Materials and methods: Twenty subjects with untreated aggressive periodontitis (stage III, grade C periodontitis) were divided into two groups: the test group (TG) received non-surgical therapy and two sessions of aPDT using a laser (HELBO TheraLite laser) with a wavelength of 670nm associated with HELBO Blue photosensitizer, and the control group (CG) received non-surgical therapy and antibiotics (amoxicillin 500mg and metronidazole 400mg, 7 days). Clinical parameters of probing depth, clinical attachment level and bleeding on probing (BOP) were assessed at baseline, 3, 6, 9 and 12 months after treatment.

Study Timeline

• Study Start: 2015-01-10
• Primary Completion: 2016-06-30
• Study Completion: 2016-06-30
• Study First Submitted: 2022-11-23
• Status Verified: 2022-12
• Study First Submitted QC: 2022-12-08
• Last Update Submitted: 2022-12-08
• Study First Posted: 2022-12-19
• Last Update Posted: 2022-12-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• aggressive periodontitis (stage III, grade C periodontitis)
• nonsmokers
• at least 20 teeth in oral cavity
• systemically healthy

Exclusion Criteria

• any previous periodontal treatment
• smoking
• pregnancy
• ingestion of systemic antibiotics within three months before therapy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
ANTIMICROBIAL PHOTODYNAMIC THERAPY	antimicrobial photodynamic therapy	The patients received antimicrobial photodynamic therapy after non-surgical periodontal treatment
SYSTEMIC ANTIBIOTICS	systemic antibiotics	The patients received systemic antibiotics after non-surgical periodontal treatment

Primary Outcome Measures

Name	Time	Method
Bleeding on probing	3 months	Bleeding after measurement of probing depth
Probing depth reduction	3 months	Change in probing depth

Secondary Outcome Measures

Name	Time	Method
Clinical attachment loss	3 months	Change in clinical attachment