Antimicrobial Photodynamic Therapy in Treatment of Aggressive Periodontitis (Stage III, Grade C Periodontitis): A Comparison Between Photodynamic Therapy and Antibiotic Therapy as an Adjunct to Non-Surgical Periodontal Treatment
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of Ljubljana
- Enrollment
- 20
- Primary Endpoint
- Bleeding on probing
Study Overview
Brief Summary
Treatment of aggressive periodontitis (stage III, grade C periodontitis) represents a big challenge. The aim of the study was to compare the long-term results of antimicrobial photodynamic therapy (aPDT) and antibiotic therapy as an adjunct to conventional non-surgical therapy in patients with aggressive periodontitis. Clinical parameters of probing depth, clinical attachment level and bleeding on probing (BOP) were assessed at baseline, 3, 6, 9 and 12 months after treatment.
Detailed Description
Background: Treatment of aggressive periodontitis (stage III, grade C periodontitis) represents a big challenge. The aim of the study was to compare the long-term results of antimicrobial photodynamic therapy (aPDT) and antibiotic therapy as an adjunct to conventional non-surgical therapy in patients with aggressive periodontitis. Materials and methods: Twenty subjects with untreated aggressive periodontitis (stage III, grade C periodontitis) were divided into two groups: the test group (TG) received non-surgical therapy and two sessions of aPDT using a laser (HELBO TheraLite laser) with a wavelength of 670nm associated with HELBO Blue photosensitizer, and the control group (CG) received non-surgical therapy and antibiotics (amoxicillin 500mg and metronidazole 400mg, 7 days). Clinical parameters of probing depth, clinical attachment level and bleeding on probing (BOP) were assessed at baseline, 3, 6, 9 and 12 months after treatment.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Single (Care Provider)
Masking Description
The blindness of the examiner was ensured by restriction of access to the patients' data. Only the supervisor (MP) had access to the allocation data and therefore knew which patients received additional aPDT treatment.
Periodontal examinations of 5 randomly selected individuals were carried out twice by the same examiner, and the second measurements were repeated after two weeks. The reproducibility of assessing all periodontal parameters was tested. Intra-examiner calibration scores were 0.95.
Eligibility Criteria
- Ages
- 18 Years to 38 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •aggressive periodontitis (stage III, grade C periodontitis)
- •nonsmokers
- •at least 20 teeth in oral cavity
- •systemically healthy
Exclusion Criteria
- •any previous periodontal treatment
- •pregnancy
- •ingestion of systemic antibiotics within three months before therapy
Arms & Interventions
ANTIMICROBIAL PHOTODYNAMIC THERAPY
The patients received antimicrobial photodynamic therapy after non-surgical periodontal treatment
Intervention: antimicrobial photodynamic therapy (Device)
SYSTEMIC ANTIBIOTICS
The patients received systemic antibiotics after non-surgical periodontal treatment
Intervention: systemic antibiotics (Drug)
Outcomes
Primary Outcomes
Bleeding on probing
Time Frame: 3 months
Bleeding after measurement of probing depth
Probing depth reduction
Time Frame: 3 months
Change in probing depth
Secondary Outcomes
- Clinical attachment loss(3 months)