NCT01032213已完成不适用
Effect of Magnesium Sulphate on Postoperative Coagulation as Measured by Thromboelastography
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- thromboelastography (TEG) analysis
研究概览
简要总结
Arterial and venous thrombotic events are the clinical manifestation of postoperative hypercoagulability. Altered serum magnesium may play a role in the balance of coagulation. In this study, the investigators investigated the effect of magnesium sulphate on the postoperative coagulation change in total intravenous anesthesia (TIVA).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •ASA Ⅰ-Ⅱ patients undergoing pelviscopic gynecologic operation under general anesthesia.
排除标准
- •Pregnancy
- •Previous known hematologic disorder
- •Recent medication interfering with hemostasis
- •Severe anemia
- •Liver disease
- •Cardiovascular or respiratory disease
研究组 & 干预措施
group C
Placebo Comparator
control group
干预措施: normal saline (Drug)
group M
Experimental
magnesium group
干预措施: Magnesium Sulfate (Drug)
结局指标
主要结局
thromboelastography (TEG) analysis
时间窗: twice
1. 10 minutes before the induction of anesthesia 2. 10 minutes after the recovery from the anesthesia
次要结局
- hemoglobin level(twice)
- platelet count(twice)
- international normalized ratio of prothrombin time (INR-PT)(twice)
- activated partial thromboplastin time (aPTT)(tiwce)
- serum magnesium level(twice)
研究者
Hyo-Seok Na
Dr.
Seoul National University Bundang Hospital
研究点 (1)
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