Effect of Magnesium Sulphate on Coagulation

Not Applicable

Completed

• Conditions: Myoma
• Interventions: Drug: normal saline; Drug: Magnesium Sulfate

• Registration Number: NCT01032213
• Lead Sponsor: Seoul National University Bundang Hospital

Brief Summary

Arterial and venous thrombotic events are the clinical manifestation of postoperative hypercoagulability. Altered serum magnesium may play a role in the balance of coagulation. In this study, the investigators investigated the effect of magnesium sulphate on the postoperative coagulation change in total intravenous anesthesia (TIVA).

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2009-12-10
• Study First Submitted QC: 2009-12-14
• Study First Posted: 2009-12-15
• Study Start: 2010-01
• Primary Completion: 2010-10
• Study Completion: 2010-10
• Status Verified: 2013-08
• Last Update Submitted: 2013-08-22
• Last Update Posted: 2013-08-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 40

Inclusion Criteria

• ASA Ⅰ-Ⅱ patients undergoing pelviscopic gynecologic operation under general anesthesia.

Exclusion Criteria

• Pregnancy
• Previous known hematologic disorder
• Recent medication interfering with hemostasis
• Severe anemia
• Liver disease
• Cardiovascular or respiratory disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
group C	normal saline	control group
group M	Magnesium Sulfate	magnesium group

Primary Outcome Measures

Name	Time	Method
thromboelastography (TEG) analysis	twice	1. 10 minutes before the induction of anesthesia; 2. 10 minutes after the recovery from the anesthesia

Secondary Outcome Measures

Name	Time	Method
hemoglobin level	twice	1. 10 minutes before the induction of anesthesia; 2. 10 minutes after the recovery from the anesthesia
platelet count	twice	1. 10 minutes before the induction of anesthesia; 2. 10 minutes after the recovery from the anesthesia
international normalized ratio of prothrombin time (INR-PT)	twice	1. 10 minutes before the induction of anesthesia; 2. 10 minutes after the recovery from the anesthesia
activated partial thromboplastin time (aPTT)	tiwce	1. 10 minutes before the induction of anesthesia; 2. 10 minutes after the recovery from the anesthesia
serum magnesium level	twice	1. 10 minutes before the induction of anesthesia; 2. 10 minutes after the recovery from the anesthesia

Trial Locations

Locations (1)

Seoul National University Bundang Hospital; 🇰🇷 Seongnam-si, Gyeonggi-do, Korea, Republic of