The Role of Lactate in Viral and Bacterial Infection
- Conditions
- Bacterial InfectionsLactate Blood IncreaseViral Infection
- Registration Number
- NCT04777747
- Lead Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
- Brief Summary
Acute upper respiratory tract infection(AURI) is common in children, and viral infection is the main cause. However, several children with viral infection are easy to suffer from secondary bacterial infection, and the mechanism is unclear.
- Detailed Description
Lactate is an important molecule in the spread and metastasis of tumor by suppressing the innate immune response. As is known, the immune system is not mature in children and it is reverse related to the age of children. An reasonable hypothesis is that the lactate is a independent risk factor in the children with viral infection progress to bacterial infection. Here, our aim is to test the hypothesis.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 400
- child's age is from 0 to 18 years
- a child is at least diagnosed with viral infection
one of the following conditions appeared:
- congenital heart disease or other abnormalities
- respiratory failure
- hereditary and/or metabolic disease
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method the level of lactate dehydrogenase(LDH) three days after admission level of LDH in both viral and viral and bacterial infection groups
level of lactate three days after admission level of lactate in both viral and viral and bacterial infection groups
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Chen
🇨🇳Chongqing, Chongqing, China
Chen🇨🇳Chongqing, Chongqing, China