The Role of Lactate From Viral to Bacterial Infection
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 400
- 试验地点
- 1
- 主要终点
- the level of lactate dehydrogenase(LDH)
研究概览
简要总结
Acute upper respiratory tract infection(AURI) is common in children, and viral infection is the main cause. However, several children with viral infection are easy to suffer from secondary bacterial infection, and the mechanism is unclear.
详细描述
Lactate is an important molecule in the spread and metastasis of tumor by suppressing the innate immune response. As is known, the immune system is not mature in children and it is reverse related to the age of children. An reasonable hypothesis is that the lactate is a independent risk factor in the children with viral infection progress to bacterial infection. Here, our aim is to test the hypothesis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 1 Minute 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •child's age is from 0 to 18 years
- •a child is at least diagnosed with viral infection
排除标准
- •one of the following conditions appeared:
- •congenital heart disease or other abnormalities
- •respiratory failure
- •hereditary and/or metabolic disease
结局指标
主要结局
the level of lactate dehydrogenase(LDH)
时间窗: three days after admission
level of LDH in both viral and viral and bacterial infection groups
level of lactate
时间窗: three days after admission
level of lactate in both viral and viral and bacterial infection groups
次要结局
未报告次要终点
研究者
Chen Long,MD
director
Children's Hospital of Chongqing Medical University