The influence of flow pattern of minimized extracorporeal circulation on end organ function – measurement of microcirculation, endothelial function and hemodynamic energy.
Phase 3
- Conditions
- I25.9Chronic ischaemic heart disease, unspecified
- Registration Number
- DRKS00009620
- Lead Sponsor
- Klinik für Herz-, Kinderherz- und Gefäßchirurgie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
Patient age > 18 years
Patient with coronary heart disease requiring bypass grafting with extracorporeal circulation
Calafiore blood cardioplegia
Written informed consent
Exclusion Criteria
Ejection fraction < 20 %
Buckberg cardioplegia
Acute coronary syndrome less than 3days before surgery
Preoperative elevated inflammatory parameters (CRP > 10 mg/l or WBC > 12x109/l)
Malignant or immunological diseases
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. intestinal and buccal blood flow and frequency<br>2. intestinal and buccal relative hemoglobin
- Secondary Outcome Measures
Name Time Method 1. Relative intestinal saturation<br>2. relative buccal Saturation<br>3. Endothelin I Expression<br>4. Energy equivalent pressure