Effects of diets containing synbiotics on gut microbiota of critically ill septic patients
Phase 2
Recruiting
- Conditions
- Sepsis is a life-threatening condition,and is a common cause of death despite advances in the supportive care of the critically ill.Sepsis,probiotics,gut microbiota
- Registration Number
- TCTR20191017004
- Lead Sponsor
- Faculty of Medicine, Prince of Songkla University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 24
Inclusion Criteria
• Age > 18 years old
• Diagnosed of sepsis, severe sepsis and septic shock according to 1992 criteria.
• Admission to medical wards, a respiratory care unit or a medical intensive care unit less than 48 hours.
• Intubation and on nasogastric tube.
• Receive antibiotic less than 48 hours.
• Able to receive enteral feeding.
Exclusion Criteria
• Terminally ill patients.
• Pregnancy.
• Diarrhea or hematochezia.
• Short bowel disease.
• History of allergy to milk or soybean.
• Contraindication to enteral feeding.
• Immunocompromised (AIDS, malignant hemopathy, neutrophil count less than 500 per mm3, cytostatic chemotherapy during the past 3 months, before ICU admission)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method ,Fecal microbial diversity (Shannon index) 3 days Rectal swabs at day 1 and 3
- Secondary Outcome Measures
Name Time Method Ventilator-associated pneumonia In-hospital Clinical and laboratory data,Nosocomial diarrhea In-hospital Clinical and laboratory data,Mortality In-hospital and 28 days Clinical data