The Efficacy of Early Screening and Treatment of Depression with Selective Serotonin Reuptake Inhibitor (SSRI) in Adult Glioma Patient
- Conditions
- Neoplasms
- Registration Number
- KCT0005453
- Lead Sponsor
- Asan Medical Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Withdrawn
- Sex
- All
- Target Recruitment
- 112
1)Understand and voluntarily sign an informed consent document prior to any study related assessment/procedures are conducted
2)First time histologically confirmed diagnosis of glioma (resection or biopsy)
3)Age =18 years and = 85 years
4)Glasgow Coma Score (GCS) 5-15
1)Unable to perform the screening test due to the neurologic deficit
2)Evidence of ongoing acute brain bleeding on CT or MRI
3)Previously confirmed diagnosis of a benign, low- or high-grade brain tumor
4)Diagnosis of systemic cancer other than glioma (breast cancer, lung cancer, gastric cancer, colon cancer etc.)
5)Currently taking antidepressant drugs
6)Previously suffered from depression in the past or within 5 years of diagnosis, and currently do not receive drug therapy
7)Taking following drugs: MAO (monoamine oxidase) inhibitor, linezolid, thioridazine, mesoridazine, pimozide, tizanidine, terfenadine, astemizole or cisapride
8)SSRI allergic history
9)On antiplatelets or anticoagulation agents (aspirin, clopidogrel, cilostazol, heparin, warfarin ?vitamin K antagonist?, DOAC ?Direct Oral Anticoagulants?)
10)On non-steroidal anti-inflammatory drug (NSAID)
11)High bleeding risk patients: hematologic disorder, thrombocytopenia ( < 50, 000/µL), coagulopathy
12)History of coronary artery disease or gastrointestinal (GI) bleeding
13)Post-anoxic coma; status epilepticus; Parkinson; central nervous system (CNS) infections (community-acquired; hospital-acquired; ventriculitis; post-operative)
14)Pregnancy or breastfeeding patient
15)Life expectancy less than 3 month
16)DNR (do not resuscitate) ordered patient
Study & Design
- Study Type
- Interventional Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Depression scale
- Secondary Outcome Measures
Name Time Method Cognitive impair scale;Neurologic deficit