Investigation of the Relationship Between Femoral Cartilage Thickness and Inflammatory Parameters, Pain Severity and Functionality in Knee Osteoarthiritis
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Knee Osteoarthritis
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
- Enrollment
- 140
- Locations
- 1
- Primary Endpoint
- Western Ontario and McMaster Universities Osteoarthritis Index
- Last Updated
- 3 years ago
Overview
Brief Summary
The aim of the study to investigate the relationship between femoral cartilage thickness in Ultrasonographic evaluation and inflammatory parameters, pain severity and functionality in participants with Knee Osteoarthritis
Detailed Description
Aim: The aim of the study is to investigate the relationship between femoral cartilage thickness and inflammatory parameters, pain severity and functionality in participants with Knee Osteoarthritis. Methods: This study is designed as a prospective, cross-sectional trial. 90 participants aged between 50-65 years with knee osteoarthritis(OA) and at least 50 participants without any symptom for knee OA are included in the study in accordance with the inclusion criteria. Participants' demographic characteristics will be evaluated, and ultrasonographic measurement will be performed for measuring femoral cartilage thickness. Visual Analog scale will be used for pain severity and Western Ontario and McMaster Universities Osteoartrit index (WOMAC) will be used for assessing functionality of the patients. Also hematologic parameters(neutrophils, leucocytes, lymphocytes, platelet, CRP, erythrocyte sedimentation rate) will be evaluated for investigating the inflammation. The relationship between femoral cartilage thickness and inflammatory parameters, pain severity and functionality in knee osteoarthritis will be analysed for both group.
Investigators
Merve Damla Korkmaz
Medical Doctor
Kanuni Sultan Suleyman Training and Research Hospital
Eligibility Criteria
Inclusion Criteria
- •diagnosed as knee osteoarthritis
- •aged between 50-65 years
- •volunteer to participate in the study
Exclusion Criteria
- •limitation of cooperation
- •moderate to severe dementia or mental retardation, which may cause limitations in examination, testing and treatment
- •refusal to participate in the study
- •pprevious total knee prosthesis surgery
- •secondary osteoarthritis
Outcomes
Primary Outcomes
Western Ontario and McMaster Universities Osteoarthritis Index
Time Frame: 1 day
evaluation of functionality
eritrocyte sedimentation rate
Time Frame: 1 day
eritrocyte sedimentation rate
neutrophil account
Time Frame: 1 day
neutrophil account
lymphocyte account
Time Frame: 1 day
lymphocyte account
platelet account
Time Frame: 1 day
platelet account
Visual Analog Scale
Time Frame: 1 day
evaluation of pain severity
monocyte account
Time Frame: 1 day
monocyte account
C-reactive protein
Time Frame: 1 day
C-reactive protein
ultrasonography
Time Frame: 1 day
measurement of femoral cartilage thickness