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Femoral Cartilage Thickness in Knee Osteoarthritis

Conditions
Knee Osteoarthritis
Interventions
Diagnostic Test: ultrasonographic measurement for femoral cartilage thickness VAS for pain severity WOMAC for functionality
Registration Number
NCT05456711
Lead Sponsor
Kanuni Sultan Suleyman Training and Research Hospital
Brief Summary

The aim of the study to investigate the relationship between femoral cartilage thickness in Ultrasonographic evaluation and inflammatory parameters, pain severity and functionality in participants with Knee Osteoarthritis

Detailed Description

Aim: The aim of the study is to investigate the relationship between femoral cartilage thickness and inflammatory parameters, pain severity and functionality in participants with Knee Osteoarthritis.

Methods: This study is designed as a prospective, cross-sectional trial. 90 participants aged between 50-65 years with knee osteoarthritis(OA) and at least 50 participants without any symptom for knee OA are included in the study in accordance with the inclusion criteria. Participants' demographic characteristics will be evaluated, and ultrasonographic measurement will be performed for measuring femoral cartilage thickness. Visual Analog scale will be used for pain severity and Western Ontario and McMaster Universities Osteoartrit index (WOMAC) will be used for assessing functionality of the patients. Also hematologic parameters(neutrophils, leucocytes, lymphocytes, platelet, CRP, erythrocyte sedimentation rate) will be evaluated for investigating the inflammation. The relationship between femoral cartilage thickness and inflammatory parameters, pain severity and functionality in knee osteoarthritis will be analysed for both group.

Recruitment & Eligibility

Status
UNKNOWN
Sex
All
Target Recruitment
140
Inclusion Criteria
  • diagnosed as knee osteoarthritis
  • aged between 50-65 years
  • volunteer to participate in the study
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Exclusion Criteria
  • limitation of cooperation
  • moderate to severe dementia or mental retardation, which may cause limitations in examination, testing and treatment
  • refusal to participate in the study
  • pprevious total knee prosthesis surgery
  • secondary osteoarthritis
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Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Arm && Interventions
GroupInterventionDescription
knee osteoarthritisultrasonographic measurement for femoral cartilage thickness VAS for pain severity WOMAC for functionalityultrasonographic measurement for femoral cartilage thickness VAS for pain severity WOMAC for functionality
healthy controlultrasonographic measurement for femoral cartilage thickness VAS for pain severity WOMAC for functionalityultrasonographic measurement for femoral cartilage thickness VAS for pain severity WOMAC for functionality
Primary Outcome Measures
NameTimeMethod
Western Ontario and McMaster Universities Osteoarthritis Index1 day

evaluation of functionality

eritrocyte sedimentation rate1 day

eritrocyte sedimentation rate

neutrophil account1 day

neutrophil account

lymphocyte account1 day

lymphocyte account

platelet account1 day

platelet account

Visual Analog Scale1 day

evaluation of pain severity

monocyte account1 day

monocyte account

C-reactive protein1 day

C-reactive protein

ultrasonography1 day

measurement of femoral cartilage thickness

Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (1)

Kanuni Sultan Suleyman Training and Research Hospital

🇹🇷

Istanbul, Kucukcekmece, Turkey

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