Changes in Joint-Cartilage as a Measure of Outcome in Juvenile Idiopathic Arthritis - Assessed by Ultrasonography and Biomarkers

University of Aarhus1 site in 1 country95 target enrollmentOctober 2009

ConditionsJuvenile Idiopathic Arthritis, Oligoarthritis Polyarticular Juvenile Rheumatoid Arthritis Systemic Juvenile Idiopathic Arthritis

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Juvenile Idiopathic Arthritis, Oligoarthritis
Sponsor: University of Aarhus
Enrollment: 95
Locations: 1
Primary Endpoint: Joint cartilage thickness
Status: Completed
Last Updated: 14 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The purpose of this study is to analyse the usability of ultrasonography together with biomarkers in the investigation of patients diagnosed with juvenile idiopathic arthritis. The investigators hypothesize that serum and urine markers of cartilage and bone synthesis and degradation, together with ultrasound measurements of joint cartilage thickness, are useful tools in the early evaluation of JIA patients, - as diagnostic, prognostic and monitoring methods.

Registry

clinicaltrials.gov

Start Date

October 2009

End Date

November 2011

Last Updated

14 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

University of Aarhus

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Juvenile idiopathic arthritis: Oligoarticular, polyarticular or systemic onset type.
•Informed consent from parents
•between 5-15 years of age

Exclusion Criteria

•Other diagnoses that involves bones or cartilage
•Intraarticular steroid injections within 1 month of the trial investigation

Outcomes

Primary Outcomes

Joint cartilage thickness

Time Frame: 1.5 years

Joint catilage thickness measured by ultrasonography: knee, ankle, wrist, metacarpophalangeal and proximal interphalangeal joints by MRI: one knee by plain radiographs: knee, ankel and wrist