Ultrasonography in Juvenile Idiopathic Arthritis

Completed

• Conditions: Juvenile Idiopathic Arthritis, Oligoarthritis; Systemic Juvenile Idiopathic Arthritis; Polyarticular Juvenile Rheumatoid Arthritis

• Registration Number: NCT01304420
• Lead Sponsor: University of Aarhus

Brief Summary

The purpose of this study is to analyse the usability of ultrasonography together with biomarkers in the investigation of patients diagnosed with juvenile idiopathic arthritis. The investigators hypothesize that serum and urine markers of cartilage and bone synthesis and degradation, together with ultrasound measurements of joint cartilage thickness, are useful tools in the early evaluation of JIA patients, - as diagnostic, prognostic and monitoring methods.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2009-10
• Study First Submitted: 2011-01-07
• Study First Submitted QC: 2011-02-23
• Study First Posted: 2011-02-25
• Primary Completion: 2011-11
• Study Completion: 2011-11
• Status Verified: 2012-03
• Last Update Submitted: 2012-03-21
• Last Update Posted: 2012-03-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 95

Inclusion Criteria

• Juvenile idiopathic arthritis: Oligoarticular, polyarticular or systemic onset type.
• Informed consent from parents
• between 5-15 years of age

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Exclusion Criteria

• Other diagnoses that involves bones or cartilage
• Intraarticular steroid injections within 1 month of the trial investigation

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Joint cartilage thickness	1.5 years	Joint catilage thickness measured by ultrasonography: knee, ankle, wrist, metacarpophalangeal and proximal interphalangeal joints by MRI: one knee by plain radiographs: knee, ankel and wrist

Secondary Outcome Measures

Name	Time	Method
Level of different biomarkers in serum and urine	1.5 years	Level of bone- and cartilage-degradation biomarkers in serum and urine. COMP, CTX-II, RANKL/OPG, PYD/DPD

Trial Locations

Locations (1)

Pediatric research dept, Aarhus Universityhospital, Skejby; 🇩🇰 Aarhus, Region Midt, Denmark