NCT01304420已完成不适用
Changes in Joint-Cartilage as a Measure of Outcome in Juvenile Idiopathic Arthritis - Assessed by Ultrasonography and Biomarkers
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 95
- 试验地点
- 1
- 主要终点
- Joint cartilage thickness
研究概览
简要总结
The purpose of this study is to analyse the usability of ultrasonography together with biomarkers in the investigation of patients diagnosed with juvenile idiopathic arthritis. The investigators hypothesize that serum and urine markers of cartilage and bone synthesis and degradation, together with ultrasound measurements of joint cartilage thickness, are useful tools in the early evaluation of JIA patients, - as diagnostic, prognostic and monitoring methods.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 5 Years 至 15 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Juvenile idiopathic arthritis: Oligoarticular, polyarticular or systemic onset type.
- •Informed consent from parents
- •between 5-15 years of age
排除标准
- •Other diagnoses that involves bones or cartilage
- •Intraarticular steroid injections within 1 month of the trial investigation
结局指标
主要结局
Joint cartilage thickness
时间窗: 1.5 years
Joint catilage thickness measured by ultrasonography: knee, ankle, wrist, metacarpophalangeal and proximal interphalangeal joints by MRI: one knee by plain radiographs: knee, ankel and wrist
次要结局
- Level of different biomarkers in serum and urine(1.5 years)
研究者
研究点 (1)
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