Articular Sonography: Healthy Subjects Versus Rheumatoid Arthritis Patients
- Conditions
- Disorders of Synovium, Multiple SitesDisorders of Cartilage, Hand JointsDisorders of Subchondral Bone, Multiple SitesArthritis, RheumatoidHealthy People
- Registration Number
- NCT01476865
- Lead Sponsor
- Federal University of São Paulo
- Brief Summary
The purpose of this study is to establish the normality of sonographic synovial measures in joints more affected in rheumatoid arthritis patients and establish, in those joints, a sonographic value of synovium predictive of rheumatoid arthritis.
- Detailed Description
Rheumatoid arthritis (RA) is a chronic inflammatory, systemic and auto-imune disorder affecting primarily the joints. In RA, inflammatory synovium causes destruction of cartilage, erosion of the adjacent bone and ultimately loss of function of the affected joint. Newer imaging techniques, such as ultrasound (US), have shown promise in evaluation of RA. Many US scoring system have been used to classify and quantify the synovium, effusion, erosion and cartilage for assessing and monitoring AR. However, its use is considered problematical because there are very few data on normal joints and, at this point, there is no clear definition of excess amount of synovium in normal people.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 190
- no articular disease (healthy group)
- establish rheumatoid arthritis (RA group)
- diabetes
- hypothyroidism- hemophilia
- pregnancy
- previous septic arthritis
- previous articular surgery
- symptomatic osteoarthritis
- no superimposed collagenoses (RA group)
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method