Prospective registry to evaluate the value of the local microbiome in the context of adhesive capsulitis, periprosthetic joint infection, and other chronic and chronic inflammatory diseases of the musculoskeletal system - FROZEN-Registry

Klinikum der Universität München, Campus Großhadern0 个研究点目标入组 100 人开始时间: 2022年8月15日最近更新: 2024年8月19日

适应症

试验速览

暂无简介。

•Clinical indication for surgery or TAPE in subsequent refractory (> 3 months (*), > 6 months (**), > 12 months (***)) to conservative measures (drug therapy, physiotherapy, intra-articular steroid injections). Subgroups: AC (*), PJI (***), others (bursitis subacromialis/ subdeltoidea/ subscapularis (*), tendinitis of the long biceps tendon (*), epicondylitis humeri radialis/ ulnaris (*), painful osteoarthritis (**)), and age = 18 years as well as regular coagulation parameters (platelets > 50. 000/mm3 or 50 GPt/l, INR/PTT <1.5 times upper normal value) and kidney function normal for age (serum creatinine/GFR) as well as signed informed consent.

•Lack of consent and/or lack of capacity to consent to the study as well as contraindications for the performance of a tissue biopsy, in particular severe blood coagulation disorder, renal insufficiency, allergies to local anesthetics, contraindications for MRI (only in the case of an MRI-guided biopsy) as well as previous arthroscopic or open surgical operations on the diseased joint (except in the case of the painful endoprosthesis) and, in the case of the endoprosthesis, mechanically associated pain, e.g. in the case of (aseptic component loosening or a material fracture) as well as systemic infection/sepsis. in case of (aseptic) component loosening or material fracture as well as systemic infection/ sepsis.

发起方

Klinikum der Universität München, Campus Großhadern