Effect of Bosentan in Patients With Non Arteritic Ischemic Optic Neuropathy
试验速览
- 阶段
- 3 期
- 状态
- 招募中
- 发起方
- 入组人数
- 86
- 试验地点
- 7
- 主要终点
- mean deviation of automated visual field
研究概览
简要总结
Acute ischemic optic neuropathy are the second leading cause of optic neuropathy after glaucoma in the population aged over 50 years. The visual prognosis of the condition is unfavorable in the great majority of cases, with significant effects on the visual field and vision. The severity of the unilateral condition is also associated with bilateralization in 15% at 5 years. There is no effective treatment for the acute phase of the disease or to reduce the rate of bilateralization. In this context, it is essential to develop new therapeutic strategies in the acute phase of the disease to reduce the anatomical optic nerve damage.
详细描述
The main objective of our study will be to compare the treatment with bosentan to placebo for 8 weeks for recovery anatomical criteria (RFNL in OCT, optic atrophy) and functional (visual acuity, visual field). The primary endpoint will be the improvement of the visual field, a major criterion of the affected visual function in this disease.
The evaluation of bosentan will mainly after 8 weeks of treatment in order to assess the effectiveness of drug treatment in the absence of continuous positive airway pressure (set up after three months if necessary, feasible confounding factor for the evaluation of results ), the period of three months is sufficient to assess the anatomical and functional recovery (disappearance of papilledema).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 50 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Non arteritic ischemic optic neuropathy (NAION) with onset < 21 days
- •Age ≥ 50 years old
- •Signed informed consent form
- •Patients affiliated with a national health insurance scheme or beneficiaries of such a scheme
排除标准
- •Pregnant women, women in labour or breast-feeding mother
- •Patients with other acute or chronic intercurrent ocular pathology interfering with visual acuity or visual field (diabetes, drug-induced or other retinopathy, other optic neuropathy including uni- or contralateral glaucoma and/or intraocular pressure > 30 mmHg, advanced cataract, corneal opacities, amblyopia < 5/10, severe myopia > -6 diopters, retinal disease)
- •Simultaneous bilateral NAAION, 1 month apart or less
- •Signs that may raise suspicion of other inflammatory neuropathy: arterial NAAION (Horton's disease), pain on eye movement or any signs suggestive of optic neuritis, known diagnosis of multiple sclerosis, history of inflammatory optic neuropathy (homo- or ipsi-lateral). A temporal artery biopsy should be performed if there are symptoms suggestive of Horton's disease, or if there is pale and/or diffuse edema, or obliteration of the associated central retinal artery.
- •Patients with systolic blood pressure below 100 mmHg
- •Patient with orthostatic hypotension (20 mmHg drop in SBP and/or 10 mmHg drop in DBP when moving to a standing position)
- •Neurological history of vascular or tumour-related changes to the visual field or other optic neuropathy
- •Systemic inflammatory disease
- •Known allergy to bosentan
- •Patients with moderate to severe hepatic impairment (Child-Pugh class B or C), biliary cirrhosis (serum levels of liver aminotransferases, aspartate aminotransferases (ASAT) and/or alanine aminotransferases (ALAT), greater than three times the upper limit of normal, bilirubin greater than twice normal)
- •Estimated glomerular filtration rate (GFR) < 30 ml/min/1.73 m2
- •Patients treated with drugs whose efficacy may be reduced by activation of cytochrome P450, 2C9, 3A4 and 2C19 isoenzymes
- •Patients treated with amiodarone
- •Patient treated with systemic corticosteroids (background treatment or treatment initiated at the time of NAAION diagnosis)
- •Person deprived of liberty by judicial or administrative decision, adult protected by law, hospitalized person
- •Ongoing participation in another clinical research study or in the exclusion period of another clinical study
研究组 & 干预措施
Bosentan
Bosentan at a dose of 125 mg two times daily, will be administered orally, twice a day, during eight weeks
干预措施: bosentan (Drug)
Placebo
placebo drug , twice a day, during eight weeks
干预措施: placebo (Drug)
结局指标
主要结局
mean deviation of automated visual field
时间窗: 3 month
Humphrey 30-2 SITA-standard
次要结局
- visual acuity(6, 12 and 24 month)
- mean deviation of automated visual field for healthy eye and NAION eye(3, 6, 12 and 24 month)
- inflammatory marker and prepro-endothelin dosing(3 month)
- optic nerve fiber layer thickness(3, 6, 12 and 24 month)
- VFQ-25 score(3 and 12 month)
- rate of bilateral occurence of NAION(at 24 month visit)
- mean deviation of automated visual field for controlateral eye(24 month)