Retinal Neuro-vascular Coupling in Patients With Non-arteritic Anterior Ischemic Optic Neuropathy

Not Applicable

Completed

• Conditions: Anterior Ischemic Optic Neuropathy
• Interventions: Device: Dynamic Vessel Analyzer (DVA); Device: Fourier Domain Doppler Optical Coherence Tomography (FDOCT); Device: Optical coherence tomography (OCT)

• Registration Number: NCT03401892
• Lead Sponsor: Medical University of Vienna

Brief Summary

Ischemic optic neuropathy is among the most common causes of serious impaired vision in the middle-aged and elderly population in the western world. The current study focuses on a subgroup of ischemic optic neuropathy, the so-called non-arteritic ischemic optic neuropathy (NAION). Although the exact pathogenesis of NAION has not been fully clarified it is known that patients with cardio-vascular risk factors such as hypertension, diabetes mellitus and dyslipidemia have also an increased risk to develop NAION. Along this line of thought it has been shown that patients with a history of NAION in one eye have an increased risk to develop NAION also on the contralateral eye. However, clinical studies investigating ocular perfusion abnormalities in patients with NAION are sparse and even contradicting. Thus, the current study seeks to measure ocular blood flow parameters in patients with a history of NAION and compare it to healthy age-matched subjects.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2018-01-10
• Study First Submitted QC: 2018-01-10
• Study First Posted: 2018-01-17
• Study Start: 2018-06-11
• Primary Completion: 2018-06-11
• Study Completion: 2018-06-11
• Status Verified: 2021-08
• Last Update Submitted: 2021-08-31
• Last Update Posted: 2021-09-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1

Inclusion Criteria

Not provided

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Exclusion Criteria

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Healthy control subjects	Dynamic Vessel Analyzer (DVA)	healthy age-and sex- matched control subjects
Patients with a history of NAION	Dynamic Vessel Analyzer (DVA)	patients with a history of non-arteritic anterior ischemic optic neuropathy (NAION) in one eye
Patients with a history of NAION	Optical coherence tomography (OCT)	patients with a history of non-arteritic anterior ischemic optic neuropathy (NAION) in one eye
Patients with a history of NAION	Fourier Domain Doppler Optical Coherence Tomography (FDOCT)	patients with a history of non-arteritic anterior ischemic optic neuropathy (NAION) in one eye
Healthy control subjects	Fourier Domain Doppler Optical Coherence Tomography (FDOCT)	healthy age-and sex- matched control subjects
Healthy control subjects	Optical coherence tomography (OCT)	healthy age-and sex- matched control subjects

Primary Outcome Measures

Name	Time	Method
Flicker light induced hyperemia in retinal vessels	1 day	Response of retinal vessels to increased neuronal activity assessed with flicker light

Secondary Outcome Measures

Name	Time	Method
Central retinal thickness	1 day	Central retinal thickness using OCT
Retinal vessel diameters	1 day	Response of retinal vessel diameters to flicker light assessed with DVA
Retinal oxygen saturation	1 day	Retinal oxygen saturation measured with DVA
Retinal blood flow	1 day	Response of retinal blood flow to flicker light assessed with FDOCT
Retinal nerve fiber layer thickness	1 day	Retinal nerve fiber layer thickness measured using OCT

Trial Locations

Locations (1)

Department of Clinical Pharmacology, Medical University of Vienna; 🇦🇹 Vienna, Austria