Retinal Neuro-vascular Coupling in Patients With Multiple Sclerosis
- Conditions
- Multiple Sclerosis, Relapsing-RemittingOptic Neuritis
- Interventions
- Device: Dynamic Vessel Analyzer (DVA)Device: Fourier Domain Doppler Optical Coherence Tomography (FDOCT)Device: Optical coherence tomography (OCT)Device: Optical coherence tomography angiography (OCTA)
- Registration Number
- NCT03401879
- Lead Sponsor
- Medical University of Vienna
- Brief Summary
Multiple sclerosis (MS) affects approximately 2.3 million patients worldwide, with a global median prevalence of 33 per 100,000. MS is diagnosed at an average of 30 years and affects twice as many women as men. MS is traditionally diagnosed by the presentation of lesions of the central nervous system, disseminated in time and in space, proven by clinical examination and magnetic resonance imaging. Several anatomical parameters in the eye, both vascular and neural, have been found to be altered in MS patients.
Because of its unique optical properties, the eye offers the possibility of the non-invasive assessment of both structural and functional alterations in neuronal tissue. As the neuro-retina is part of the brain, it does not come as a surprise that neuro-degenerative changes in the brain are accompanied by structural and possibly also functional changes in the neuro-retina and the ocular vasculature.
The current study seeks to test the hypothesis that beside the known anatomical changes, also functional changes can be detected in the retina of patients with MS. For this purpose, flicker light induced hyperemia will be measured in the retina as a functional test to assess the coupling between neural activity and blood flow. Further, structural parameters such as retinal nerve fiber layer thickness and function parameters such as ocular blood flow and retinal oxygenation will be assessed and compared to age and sex matched controls.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 50
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Patients with MS Optical coherence tomography angiography (OCTA) Patients with Multiple Sclerosis Patients with MS Dynamic Vessel Analyzer (DVA) Patients with Multiple Sclerosis Healthy control subjects Optical coherence tomography (OCT) Healthy age- and sex- matched control subjects Patients with MS Fourier Domain Doppler Optical Coherence Tomography (FDOCT) Patients with Multiple Sclerosis Healthy control subjects Optical coherence tomography angiography (OCTA) Healthy age- and sex- matched control subjects Patients with MS Optical coherence tomography (OCT) Patients with Multiple Sclerosis Healthy control subjects Dynamic Vessel Analyzer (DVA) Healthy age- and sex- matched control subjects Healthy control subjects Fourier Domain Doppler Optical Coherence Tomography (FDOCT) Healthy age- and sex- matched control subjects
- Primary Outcome Measures
Name Time Method Flicker induced increase in retinal blood flow 1 day Response of retinal blood flow to flicker light assessed with FDOCT
- Secondary Outcome Measures
Name Time Method Layer specific flow signal 1 day Retinal layer specific blood flow signal measured using OCTA
Retinal vessel diameters 1 day Response of retinal vessel diameters to flicker light assessed with DVA
Retinal oxygen saturation 1 day Retinal oxygen saturation measured with DVA
Retinal nerve fiber layer thickness 1 day Retinal nerve fiber layer thickness measured using OCT
Trial Locations
- Locations (1)
Department of Clinical Pharmacology, Medical University of Vienna
🇦🇹Vienna, Austria