The interaction of intravenous s-ketamine on sevoflurane anesthesia
- Conditions
- We want to test if intravenous s-ketamine of two different doses has an effect on MAC of sevofluraneTherapeutic area: Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03]
- Registration Number
- EUCTR2012-001908-38-AT
- Lead Sponsor
- Medizinische Universität Wien, Universitätsklinik für Anästhesie, Allgemeine Intensivmedizin und Schmerztherapie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Recruiting
- Sex
- All
- Target Recruitment
- 61
elective surgery with general anaesthesia in supine position
age 30-65 years
skin incision of at least 3 cm at the trunk
ASA 1-3
signed informed consent
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range 120
F.1.3 Elderly (>=65 years) no
F.1.3.1 Number of subjects for this age range 0
subjects not able to understand study procedures
premedication
contraindication for inhalational induction
BMI > 30 and < 18,5
patients with significant cardiovascular, respiratory, hepatic or renal disease
patients with history of alcohol or drug abuse
psychiatric disorders
known allergy on ketamine or inhalative anaesthetics
pregnancy
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Main Objective: Does intravenous s-ketamine reduce the MAC value of Sevoflurane;Secondary Objective: Has intravenous ketamine an effect on heart rate, blood pressure and bispectral index monitoring;Primary end point(s): Movement at skin incision;Timepoint(s) of evaluation of this end point: skin incision
- Secondary Outcome Measures
Name Time Method Secondary end point(s): heart rate, blood pressure and bispectral index values at skin incision;Timepoint(s) of evaluation of this end point: skin incision