Lipid and Carbohydrate Metabolism: Effects of Exercise
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 41
- 试验地点
- 2
- 主要终点
- change in de novo lipogenesis
研究概览
简要总结
The purpose of this study was to examine the pathophysiology of insulin resistance and the relation to the metabolic syndrome in humans.
详细描述
In this study insulin resistant (IR), young offspring of parents with type 2 diabetes (18-46 years) and healthy, lean elderly individuals (65-90 years) underwent 1H/13C MRS measurements of liver and muscle lipid and glycogen content before and after a high carbohydrate meal challenge. Hepatic de novo lipogenesis was determined as the incorporation of deuterium, from deuterium labeled water (2H2O), into plasma triglycerides 5. These metabolic studies were performed in 2 sets: Study Part 1: Resting, Study Part 2: After 1 bout of 45 minutes exercise.
The study has been completed and published as two papers: August 16, 2011 and July 24, 2012.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Body Mass Index < 29 kg/m2
- •No regular exercise routine
- •Non-smokers
- •Absence of systemic and organ disease.
排除标准
- •Hematocrit < 35 vol%
- •History of claustrophobia
- •Ferromagnetic implants
- •Regular exercise regimen
- •Not weight stable
- •Any significant hematological, neurological, musculoskeletal or endocrine disease (including diabetes mellitus)
- •Any significant cardiovascular condition, including confirmed CAD and prior cardiovascular events
- •Taking coumadin as anticoagulant therapy.
结局指标
主要结局
change in de novo lipogenesis
时间窗: Baseline
At the baseline assessment, de novo lipogenesis was assessed after a high carbohydrate meal and a drink of heavy water. Muscle glycogen and lipid contents were measured pre- and post meal using 1H/13C MRS and de novo lipogenesis was assessed from the heavy water incorporation into blood lipid in samples collected overnight.
次要结局
未报告次要终点