Study of the Role of Insulin Resistance in the Pathogenesis of the Metabolic Syndrome and of Non-alcoholic Steatohepatitis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 41
- 试验地点
- 2
- 主要终点
- plasma triglycerides
研究概览
简要总结
The purpose of this study is to assess how the macronutrient composition of the diet effects
- lipid and glucose metabolism
- intrahepatic lipids
- insulin sensitivity
in healthy lean subjects and in subjects with a high metabolic risk (ie overweight and offsprings of patients with type 2 diabetes mellitus).
详细描述
The study is aimed at assessing the effects of changes in total energy, sugars, lipids, and protein intake on intrahepatic lipids, plasma lipids, and hepatic and whole body insulin resistance in
- lean men and women with no family history of diabetes
- overweight men and women
- lean men with a family history of type 2 diabetes
Subjects are studied after a 6-day period of
- isocaloric diet with 100% calorie requirement, of which 55% carbohydrate, 15% protein, and 30% fat)
- the same isocaloric diet supplemented with 3g/kg body weight/day fructose
- hypercaloric high fat diet with 130% energy requirement, of which 55% carbohydrate, 15% protein, 60% fat
- hypercaloric high fat+protein diet with 145% energy requirement, of which 55% carbohydrate, 30% protein, 60% fat
Measurements performed after 6 days on each diet include
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Males and females
- •Age 18-40
- •Informed consent obtained
- •Subgroup with overweight (body mass index [BMI] > 25)
- •Subgroup with family history of type 2 diabetes mellitus
排除标准
- •Alcohol intake > 30g/day
- •Drug abuse
- •Diabetes mellitus
- •Any concurrent medication
- •Having a pacemaker
- •History of orthopedic surgery
- •History of metal foreign bodies
研究组 & 干预措施
normal weight male high fructose diet
Effects of diet intervention " high fructose" in normal weight subjects
干预措施: diet intervention (Other)
offsprings of T2DM high fructose diet
Effect of diet intervention "high fructose" in healthy non-obese offsprings of patients with type 2 diabetes
干预措施: diet intervention (Other)
normal weight subjects high fat diet
effects of diet intervention "high fat" in healthy male subjects
干预措施: diet intervention (Other)
Normal weight high fat+protein diet
effect of diet intervention "high fat + protein" subjects in healthy male subjects
干预措施: diet intervention (Other)
结局指标
主要结局
plasma triglycerides
时间窗: 6 days
intra-hepatic lipids
时间窗: 6 days
insulin mediated glucose disposal
时间窗: 6 days
次要结局
- lipid oxidation(6 days)
- plasma beta-hydroxybutyrate(6 days)
- gene expression in skeletal muscle and adipose tissue(6 days)
研究者
Luc Tappy, MD
Professor Luc Tappy
University of Lausanne