Radiomics-based Non-invasive Classifier Research for HCC-related Liver Transplantation

• Conditions: Liver Transplantation; Hepatocellular Carcinoma; Magnetic Resonance Imaging
• Interventions: Other: Risk model of tumor relapse

• Registration Number: NCT03981848
• Lead Sponsor: Zhejiang University

Brief Summary

The purpose of this study is to establish a non-invasive radiomics method to filter high recurrent-risk liver transplantation recipient population

Detailed Description

Hepatocellular carcinoma is one of the most common malignant tumors in the world with high incidence and mortality. Liver transplantation is the most effective treatment for HCC and is in high demand in China. However, recurrence of HCC among liver transplantation recipients is still a great challenge and threat to the survival of recipients. So it is of great significance to establish a non-invasive way to filter high liver transplantation recipient population before transplantation. Based on large scales of pre-treatment MR images, the investigator's study aims to establish a non-invasive radiomics method to filter high recurrent-risk liver transplantation recipient population. This study will contribute to the precise selection of HCC-related liver transplantation recipients.

Study Timeline

• Status Verified: 2019-06
• Study First Submitted: 2019-06-10
• Study First Submitted QC: 2019-06-10
• Last Update Submitted: 2019-06-10
• Study First Posted: 2019-06-11
• Last Update Posted: 2019-06-11
• Study Start: 2019-07
• Primary Completion: 2021-07
• Study Completion: 2021-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• All patients had postoperative pathological diagnosis of HCC
• All patients had underwent contrast-enhanced MRI scan within 2 weeks before liver transplantation

Exclusion Criteria

• patients whose pathological diagnosis is not HCC
• patients whose CT images were affected by strong imaging artifacts, i.e. artifacts obscuring more than 10% of whole volume of interest
• patients whose clinical data or CT images were missing

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Non-relapse	Risk model of tumor relapse	Non-relapse of tumor within two years after liver transplantation
Relapse	Risk model of tumor relapse	Relapse of tumor within two years after liver transplantation

Primary Outcome Measures

Name	Time	Method
tumor recurrent status	two years