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临床试验/NCT02844413
NCT02844413已完成4 期

The Influence of Regular Aerobic Interval Training on Blood Pressure and Arterial Stiffness Amongst Hypertensive Subjects

Jagiellonian University0 个研究点目标入组 60 人开始时间: 2015年12月1日最近更新:
适应症

试验速览

阶段
4 期
状态
已完成
发起方
入组人数
60
主要终点
Pulse wave velocity augmentation of 1.04 [m/s]

研究概览

简要总结

Regular exercise is recommended as an adjuvant treatment in hypertensive subjects by both European and American guidelines. Crucially, however, there are no precise recommendations on the type of physical exercise and how it should be instituted A relatively short period (5 months) of regular aerobic interval training (AIT), significantly decreased blood pressure, pulse wave velocity, and most applanation tonometry indexes in hypertensive subjects also undertaking pharmacological treatment in our study.

详细描述

Regular physical exercise appears to potentiate the effects of pharmacological treatment for arterial hypertension. As such, regular exercise is recommended as an adjuvant treatment in hypertensive subjects by both European and American guidelines. Crucially, however, there are no precise recommendations on the type of physical exercise and how it should be instituted. Aerobic Interval Training (AIT) is a new and novel type training that appears to be beneficial to patients suffering from various medical conditions. There is a distinct lack of evidence on how it affects arterial hypertension. The aim of this study was to evaluate the influence of a 5 month period of regular AIT on blood pressure, carotid femoral pulse wave velocity (PWV) and applanation tonometry indexes in patients previously treated pharmacologically for mild or moderate arterial hypertension.

The study group consisted of 60 hypertensive subjects (30 males, 30 females) (age 54.45 ± 8.52 years) who had previously undergone at least 2 years of combined anti-hypertensive therapy and who had well controlled hypertension, i.e. below 140/90 mmHg. Their pharmacological treatment did not change during the study period. The study group was randomly divided into 2 subgroups. In the first group (G1), AIT was undertaken for 5 months (40 professional AIT sessions performed two times per week in 50 minute sessions) and followed a specially developed program. The second control group (G2), did not attend any training sessions but received medical advice on how to maintain physical activity as outlined by JNC (Joint National Committee) hypertension guidelines. During the baseline visit and then at five months (final visit), both groups underwent testing for office BP (blood pressure), PWV and applanation tonometry indexes using the SphygmoCor® device and the Complior® device.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Prevention
盲法
None

入排标准

年龄范围
51 Years 至 59 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • subjects who have had previously undergone at least 2 years of combined antihypertensive therapy and who had well controlled hypertension, i.e. below 140/90 mmHg
  • subjects whos pharmacological treatment did not change during the study period

排除标准

  • Secondary hypertension
  • Chronic kidney or liver failure
  • Grade 3 hypertension as defined by European Society of Hypertension 2013
  • Chronic obstructive pulmonary disease
  • The need for the use of 3 antihypertensives
  • Diabetes or other illness affected carbohydrate metabolism
  • Previous myocardial infarction
  • Other serious conditions which might shorten survival time
  • Previous stroke or transient ichemic attack (TIA)
  • Other conditions affecting the locomotor system which would significantly limit the ability to undertake exercise
  • Symptomatic heart failure
  • Lack of informed consent

结局指标

主要结局

Pulse wave velocity augmentation of 1.04 [m/s]

时间窗: 5 months

次要结局

  • systolic blood pressure reduction of 3.9 [mmHg] and diastolic blood pressure reduction of 2.7 [mmHg](5 months)

研究者

发起方
Jagiellonian University
申办方类型
Other
责任方
Principal Investigator
主要研究者

Tomasz Kameczura

MD, PhD

Jagiellonian University

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