Acquired Syphlis by Non Sexual Contact

Completed

• Conditions: Syphilis Acquired; Syphilis Infection

• Registration Number: NCT04455425
• Lead Sponsor: Hospital de Niños R. Gutierrez de Buenos Aires

Brief Summary

Syphilis is classically described as a sexually transmitted disease. As this source of contagious has been described long ago -mainly though by observation- when children presents with acquired syphilis, child abuse is always considered and must be ruled out by specialists in a careful evaluation.

However, muco-cutaneous lesions can be a contagious source for congenital syphilis; therefore the possibility of non-sexual transmission through intimate contact with infected people through humid lesions (such as in kisses, breastfeeding, food-handling) or contaminated fomites (towels, bed sheets, underwear, cups, pacifiers, cutlery) could be considered. Experts worldwide have observed this non-sexual transmission, as described in many reports in literature.

The investigators will study retrospectively patients from a cohort with non-sexual transmission. The diagnosis criteria used for acquired syphilis were as follows: age under 18 years with treponemic and nontreponemic positive tests, secondary-syphilis suspicious lesions and negative maternal syphilis serology. Nonsexual contagious was defined as contacts without physical and psychosocial indicators of sexual abuse according to current guides. In this cohort, in every case a psychosocial evaluation was completed with a written report in order to evaluate sexual contact probability.

The teamo will describe these patients clinical and laboratory findings, family and close acquaintances serologies and probable source of contagious.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-06-29
• Study First Submitted QC: 2020-06-29
• Study First Posted: 2020-07-02
• Study Start: 2020-07-15
• Primary Completion: 2021-04-15
• Study Completion: 2021-05-15
• Status Verified: 2023-02
• Last Update Submitted: 2023-02-28
• Last Update Posted: 2023-03-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Describe serology titers from patients with non - sexually acquired syphilis and from their close contacts	Past 20 years	Investigators will report serology titers from patients with non - sexually acquired syphilis at diagnose and follow-up until cure, and from their close contacts at diagnose and during follow up of those resulting positive at contact screening
Describe reported symptoms and physical findings at diagnose and during follow-up f children with assumed non-sexual acquired syphilis and their close contacts	Past 20 years	Investigators will describe symptoms and physical findings from patients with non - sexually acquired syphilis at diagnose and follow-up until cure, and from their close contacts at diagnose and during follow up of those resulting positive at contact screening
Describe diagnose process of a cohort of children with assumed non-sexual acquired syphilis	Past 20 years	Describe the interdisciplinary approach of patients with acquired syphilis and how non-sexual transmission was assumed

Trial Locations

Locations (1)

Hospital de Niños Ricardo Gutierrez; 🇦🇷 Buenos Aires, Capital Federal, Argentina