Effects of calcium and amino acids on gut hormone secretions and bone turnover in healthy males

Not Applicable

Completed

• Conditions: Healthy human gastrointestinal physiology; Healthy human bone turnover physiology; Diet and Nutrition - Obesity; Oral and Gastrointestinal - Normal oral and gastrointestinal development and function; Metabolic and Endocrine - Normal metabolism and endocrine development and function; Musculoskeletal - Normal musculoskeletal and cartilage development and function

• Registration Number: ACTRN12620001294943
• Lead Sponsor: Christine Feinle-Bisset

Brief Summary

Intraduodenal administration of calcium enhances the effect of Trp to suppress energy intake, associated with greater stimulation of GI hormones secretion, in health.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-11-30
• Study Completion: 2022-04-20
• Last Update Posted: 20 November 2023

Recruitment & Eligibility

• Status: Completed
• Sex: Male
• Target Recruitment: 15

Inclusion Criteria

Healthy
Lean weight (BMI 19-25 kg/m2)

Exclusion Criteria

Each participant will be questioned prior to the study to exclude:
-significant GI symptoms, disease or surgery
-use of prescribed or non-prescribed medications (including vitamins and herbal supplements) which may affect energy metabolism, GI function, body weight or appetite (e.g. domperidone, cisapride, anticholinergic drugs (e.g. atropine), metoclopramide, erythromycin, hyoscine, orlistat, green tea extracts, Astragalus, St Johns Wort etc.)
-lactose intolerance/other food allergy(ies)
-current gallbladder or pancreatic disease
-cardiovascular or respiratory diseases
-individuals with low ferritin levels (females <15 ng/mL, males <30 ng/mL), or who have donated blood in the 12 weeks prior to taking part in the study
-any other illnesses as assessed by the investigator (including chronic illnesses not explicitly listed above)
-high performance athletes
-current intake of > 2 standard drinks on > 5 days per week
-current smokers of tobacco (cigarettes, cigars, pipes, sheesha, chewing, vaping etc.)
- recreational drug use, e.g marijuana
-current intake of any illicit substance
-vegetarians
-inability to tolerate nasoduodenal tube
-inability to comprehend study protocol
-restrained eaters (score >12 on the 3-factor eating questionnaire)

Study & Design

• Study Type: Interventional
• Study Design: Not specified