Assessment of Postoperative Lymphopenia as Risk Factor for Postoperative Infections: EVALYMPH Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1,125
- 试验地点
- 20
- 主要终点
- Presence of post operative infection
研究概览
简要总结
Postoperative infections are one of the most common complications in thoracic and digestive cancer surgery. Former studies have demonstrated that inflammatory response is altered during peri-operative period causing lymphopenia. It has been suggested that lymphopenia may contribute to postoperative infection. To date, no one has proved it in a multivariate analysis. The aim of this study is to determine if lymphopenia is associated with postoperative infections in thoracic and digestive cancer surgery.
详细描述
Postoperative infections are one of the most common complications in thoracic and digestive cancer surgery. Former studies have demonstrated that inflammatory response is altered during peri-operative period causing lymphopenia. It has been suggested that lymphopenia may contribute to postoperative infection. To date, no one has proved it in a multivariate analysis.
The aim of this study is to determine if lymphopenia is associated with postoperative infections in thoracic and digestive cancer surgery. It is a multicenter French cohort study. Lymphocytes counts are obtained from patients undergoing pulmonary or digestive cancer surgery before surgery (day-0) as well 1, 3, 5 and 8 days after surgery. Anesthetic and surgical procedures are collected as well as risk factors for postoperative infections recognized in the literature. Clinical and biological signs of infection are collected.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patient undergoing digestive or thoracic cancer surgery under general anesthesia.
排除标准
- •pregnant women,
- •malignant blood disease,
- •allograft patient,
- •preoperative sepsis or preoperative systemic inflammatory response syndrome.
结局指标
主要结局
Presence of post operative infection
时间窗: 1 month
Patients undergoing general anesthesia for thoracic or digestive surgery could present lymphopenia. In this situation, the presence of post operative infection is notified. The correlation between lymphopenia and post operative infections is studied.
次要结局
- Anesthetic and surgical parameters(1 month)