跳至主要内容
临床试验/NCT03549546
NCT03549546已完成不适用

Expression of the Inhibitory Receptors on Lymphocytes T Cells After Lung Cancer Surgery.

Centre Hospitalier Universitaire de Saint Etienne1 个研究点 分布在 1 个国家目标入组 31 人开始时间: 2018年6月14日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
入组人数
31
试验地点
1
主要终点
PD-1, TIM-3, CTLA4 on CD4/CD8 lymphocytes

研究概览

简要总结

Postoperative pneumonia is one of the most common complications after lung cancer surgery and associated with a morbidity and mortality. Postoperative lymphopenia has been recently identified as one of risk factors for postoperative pneumonia. According to recent studies in polytrauma, cancer or septic shock, T cells dysfunction may be related to high expression of inhibitory receptors on lymphocytes.

详细描述

This study will investigate prospectively TIM-3, PD-1 and CTLA4 expression on lymphocytes T cells before and after lung cancer surgery. Patients ≥ 18 years with no history of immunosuppressive state will be included.

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Basic Science
盲法
None

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Patient ≥ 18 years undergoing lung cancer surgery by thoracoscopy

排除标准

  • Patient under guardianship/curatorship
  • Patient who received of radiotherapy or chemotherapy in the last 6 months
  • Patient under immunosuppressive treatment or dose of corticoids over 10 mg/day prednisolone or equivalent
  • Patient with history of malignant blood disease or auto-immune disease
  • Patient suffering from HIV infection and
  • Patients with pre-operative infection
  • Patient with an empiric antibiotic therapy introduced at operating room

研究组 & 干预措施

Patients undergoing lung cancer surgery

Other

Patients undergoing lung cancer surgery will be included. Blood samples will be collected.

干预措施: Blood samples (Biological)

结局指标

主要结局

PD-1, TIM-3, CTLA4 on CD4/CD8 lymphocytes

时间窗: Days 0, 1, 3

Correlation between expression of PD-1, TIM-3, CTLA4 on CD4/CD8 lymphocytes and the occurrence of lymphopenia. Measured by blood sample before lung cancer surgery, the next day lung cancer surgery and 3 days after lung cancer surgery. Analyzed by multicolour immunolabelling in flow cytometry

次要结局

  • functionality of CD4/CD8 lymphocytes and production of IF gamma, TNF and IL-2(Days 0, 1, 3)
  • pneumonia(Days 3)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

Loading locations...

相似试验