Expression of the Inhibitory Receptors on Lymphocytes T Cells After Lung Cancer Surgery.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 31
- 试验地点
- 1
- 主要终点
- PD-1, TIM-3, CTLA4 on CD4/CD8 lymphocytes
研究概览
简要总结
Postoperative pneumonia is one of the most common complications after lung cancer surgery and associated with a morbidity and mortality. Postoperative lymphopenia has been recently identified as one of risk factors for postoperative pneumonia. According to recent studies in polytrauma, cancer or septic shock, T cells dysfunction may be related to high expression of inhibitory receptors on lymphocytes.
详细描述
This study will investigate prospectively TIM-3, PD-1 and CTLA4 expression on lymphocytes T cells before and after lung cancer surgery. Patients ≥ 18 years with no history of immunosuppressive state will be included.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient ≥ 18 years undergoing lung cancer surgery by thoracoscopy
排除标准
- •Patient under guardianship/curatorship
- •Patient who received of radiotherapy or chemotherapy in the last 6 months
- •Patient under immunosuppressive treatment or dose of corticoids over 10 mg/day prednisolone or equivalent
- •Patient with history of malignant blood disease or auto-immune disease
- •Patient suffering from HIV infection and
- •Patients with pre-operative infection
- •Patient with an empiric antibiotic therapy introduced at operating room
研究组 & 干预措施
Patients undergoing lung cancer surgery
Patients undergoing lung cancer surgery will be included. Blood samples will be collected.
干预措施: Blood samples (Biological)
结局指标
主要结局
PD-1, TIM-3, CTLA4 on CD4/CD8 lymphocytes
时间窗: Days 0, 1, 3
Correlation between expression of PD-1, TIM-3, CTLA4 on CD4/CD8 lymphocytes and the occurrence of lymphopenia. Measured by blood sample before lung cancer surgery, the next day lung cancer surgery and 3 days after lung cancer surgery. Analyzed by multicolour immunolabelling in flow cytometry
次要结局
- functionality of CD4/CD8 lymphocytes and production of IF gamma, TNF and IL-2(Days 0, 1, 3)
- pneumonia(Days 3)