Oral Infections: Dietary Regulation of Local and Systemic Inflammatory Responses
Not Applicable
Completed
- Conditions
- Periodontal Attachment Loss
- Interventions
- Dietary Supplement: Omega-3 Fatty acid (with SRP or OHI)Dietary Supplement: Placebo
- Registration Number
- NCT00632957
- Lead Sponsor
- University of Kentucky
- Brief Summary
The purpose of this study is to test the hypothesis that dietary n-3 PUFA will have a beneficial effect on systemic and local markers of inflammation when combined with traditional, non-surgical periodontal therapy.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 126
Inclusion Criteria
- ≥ 18 years of age, male or female
- At least 20 natural teeth present at the time of periodontal examination
- Be diagnosed with severe, chronic periodontitis;
- Be willing to participate in the study
Exclusion Criteria
- <18 years of age
- Less than 20 natural teeth present at time of periodontal examination
- Unable or unwilling to provide informed consent or follow study protocol
- Systemic conditions including diabetes mellitus and any cardiovascular condition that would require premedication prior to dental treatment
- Use of systemic antibiotics within the last 3 months
- Pregnancy as diagnosed by administered pregnancy test.
- You are nursing a baby.
- Are allergic to fish or fish products.
- You are taking any other medications, such as dietary supplements, that could affect the outcome of the study
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Fish oil Omega-3 Fatty acid (with SRP or OHI) - Placebo Placebo -
- Primary Outcome Measures
Name Time Method clinical attachment loss baseline, 8, 16, 28 weeks
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University of Kentucky College of Dentistry
🇺🇸Lexington, Kentucky, United States