Adductor Canal Block Versus Periarticular Infiltration Effect on Functional Outcome In Patients Undergoing Total Knee Replacement
试验速览
- 阶段
- 不适用
- 入组人数
- 200
- 主要终点
- "Timed Up and Go" test (TUG)
研究概览
简要总结
TKA involves extensive bone resection as well as soft tissue excision and therefore is associated with profound postoperative pain. Adequate analgesia after TKA is therefore considered paramount to facilitate early hospital discharge and effective functional recovery.
详细描述
Osteoarthritis (OA) of the knee has become a major public health issue and imposes a significant healthcare burden and accounts for high annual hospitalizations. Chronic OA of the knee may lead to reduced physical fitness, mobility disability with a resultant increased risk of cardio-metabolic comorbidity and early mortality. Total knee arthroplasty (TKA) is indicated in severe cases to improve long-term pain and function. (1) TKA involves extensive bone resection as well as soft tissue excision and therefore is associated with profound postoperative pain. (2) Inadequate perioperative pain control may prolong hospitalization, hinder early rehabilitation, and is also a strong predictor of persistent pain beyond 3 months. (3) Adequate analgesia after TKA is therefore considered paramount to facilitate early hospital discharge and effective functional recovery. (4) The recently introduced adductor canal block (ACB) typically covers the anterio-medial aspect of the knee and preserves quadriceps function, which presumably enhances postoperative rehabilitation by allowing patients to actively participate in knee movement. The relative effectiveness of this ACB technique added to intrathecal morphine is limited to a single study (1) in which assessment of short-term functional recovery was done and dexamethasone was neither included in the LIA solution nor perineurally in the ACB. Thus, we hypothesize that adductor canal block as an adjunct to intrathecal morphine will have a better impact on functional recovery than peri-articular infiltration.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 45 Years 至 85 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •American Society of Anesthesiologist class ( ASA) I - III
- •BMI 18-35 kg/m2
- •Scheduled for primary unilateral TKR
排除标准
- •Known allergy to local anesthetics
- •Contraindication to adductor canal block e.g. infection at the site of injection
- •Contraindication to spinal anesthesia e.g. coagulopathy.
- •Patients with pre-existing motor or sensory deficits in lower extremities.
- •Patients who are morbidly obese (BMI≥35) because ultrasound-guided regional anesthesia could be technically difficult.
- •Bilateral or revision total knee replacement
- •Insulin or noninsulin-dependent diabetes mellitus.
- •systemic corticosteroid use within 30-days of surgery
结局指标
主要结局
"Timed Up and Go" test (TUG)
时间窗: 48 hours
reflects the time it takes a subject to stand up from a standard-height armchair, walk 3 m, walk back to the chair, and sit down.
次要结局
- Visual analogue scale (VAS) at rest(72 hours)
- Visual analogue scale (VAS) at movement(72 hours)
- Time to first analgesic request(72 hours)
- Total analgesic consumption(72 hours)
研究者
Shimaa Abbas Hassan
lectrure of Anesthesia
Assiut University
