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临床试验/NCT06282640
NCT06282640已完成4 期

Comparıson Of Electromyography Results Before And After Vıtamın D Treatment In Patıents Wıth Carpal Tunnel Syndrome

Dr. Ayşe Güç1 个研究点 分布在 1 个国家目标入组 87 人开始时间: 2021年12月30日最近更新:
适应症
干预措施
相关药物

试验速览

阶段
4 期
状态
已完成
发起方
入组人数
87
试验地点
1
主要终点
electrophysiological scale.

研究概览

简要总结

Therefore, we aimed to evaluate the effectiveness of vitamin D replacement therapy on pain, electrophysiological parameters, ultrasonographic measurement results and functional status scales in CTS patients with low serum vitamin D levels.

详细描述

Introduction

Apart from its effect on bone health, vitamin D is also known to have beneficial effects on the neurological system. In studies, vitamin D levels were found to be low in patients with Carpal Tunnel Syndrome (CTS). However, studies examining the effects of vitamin D replacement on CTS are limited. Therefore, we aimed to evaluate the effectiveness of vitamin D replacement therapy on pain, electrophysiological parameters, ultrasonographic measurement results and functional status scales in CTS patients with low serum vitamin D levels. Materials and Methods: Our study was planned as an observational and analytical prospective. Vitamin D loading therapy was given to patients with serum vitamin D levels below 20ng/ml and mild-moderate CTS detected by electroneuromyography (ENMG). Patients with vitamin D levels above 20 ng/ml after 8 weeks were included in the study. Each patient was given a rest splint and exercise program. Patients were evaluated before and 3 months after treatment with electrophysiological, ultrasonographic, VAS, pinch-grip strength, two-point discrimination, monofilament test and Boston symptom severity scale.

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Prevention
盲法
None

入排标准

年龄范围
18 Years 至 70 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • 18-70 years old male or female gender
  • Those with mild to moderate CTS according to ENMG,
  • Vitamin D level <20.

排除标准

  • Severe CTS according to ENMG
  • Thenar region atrophy
  • diabetes mellitus,
  • rheumatoid arthritis,
  • hyperthyroidism,
  • hypothyroidism
  • Traumatic nerve injury, history of surgery
  • Polyneuropathy
  • Pregnancy
  • Severe psychiatric illness
  • Poor orientation and cooperation,
  • Injection (corticosteroid, ozone, stem cell...) applied for CTS treatment within 3 months

研究组 & 干预措施

Vitamin D in Carpal Tunnel Syndrome

Experimental

干预措施: Vitamin D (Drug)

结局指标

主要结局

electrophysiological scale.

时间窗: at the baseline and immediately after treatment

Electrophysiological Evaluation: Neurowerk (SIGMA-Medizin-TechnicGmbH/Germany) brand ENMG device was used. Patients were evaluated at room temperature of approximately 25 °C. All measurements were made by the same doctor. Our clinic's reference values for the diagnosis of CTS are shown below

次要结局

  • monofilament test(at the baseline and immediately after treatment)

研究者

发起方
Dr. Ayşe Güç
申办方类型
Other Gov
责任方
Sponsor Investigator
主要研究者

Dr. Ayşe Güç

medical doctor

Kayseri Education and Research Hospital

研究点 (1)

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