Curcumin for the Management of Periodontitis andEarly Rheumatoid Arthritis: KillingTwo Birds with One Stone

Not Applicable

• Conditions: Health Condition 1: K053- Chronic periodontitis

• Registration Number: CTRI/2020/11/029047
• Lead Sponsor: Dr Manjunath S M

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 24 November 2021

Recruitment & Eligibility

• Status: ot Yet Recruiting
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

1)Patients suffering from chronic periodontitis.

2)Probing pocket depth >=5mm.

3)Clinical attachment loss >=3mm.

4)Number of remaining teeth >=20 excluding third molars.

5)Patients suffering from chronic periodontitis and early stages of rheumatoid arthritis.

6)With elevated ESR( >30mm/hr.),

7)C- Reactive Protein( >10.0mg/l),

8)Rheumatoid factor ( >20U/ml),

9)Anticyclic citrullinate peptide ( >20U/ml).

10)Rheumatoid arthritis patients, who are not on disease-modifying anti-rheumatic drugs, or DMARDs

11)Patients between age group 20-65 years.

12)Patients with no history of allergy to drugs used or prescribed in this study

Exclusion Criteria

1)Rheumatoid arthritis patients, who are on disease-modifying anti-rheumatic drugs, or DMARDs

2)Pregnant and lactating females.

3)Patients who have undergone periodontal treatment within a period of 6 months.

4)Patients with plaque index > 1 and who donâ??t follow oral hygiene instructions after phase I therapy.

5)Patients on steroid therapy and oral contraceptives.

6)History of tobacco chewing and current or former smoker.

7)Patients who did not accept terms and conditions of the study.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1.To study the effect of nutritional supplementation with curcumin on Alkaline Phosphatase levels in gingival crevicular fluid of patients with chronic periodontitis. <br/ ><br>2.To Compare and Evaluate the effect of nutritional supplementation with curcumin on Alkaline Phosphatase levels in gingival crevicular fluid of patients with chronic periodontitis and rheumatoid arthritis patients. <br/ ><br>3.To study the use of curcumin as an adjunct in the treatment of periodontal diseases <br/ ><br>Timepoint: at base line and 6 weeks

Secondary Outcome Measures

Name	Time	Method
not applicableTimepoint: not applicable