Coagulation and wound healing of open vs. minimally invasive esophageal and pancreatic surgery - focus on factor XIII

• Conditions: Acquired deficiency of clotting factor XIII

• Registration Number: DRKS00028547
• Lead Sponsor: Klinik für AnästhesiologieUniversitätsklinikum Heidelberg

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2022-04-14
• Study Completion: 2023-12-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 113

Inclusion Criteria

Age = 18 years
- Existing capacity to give consent
- Patients undergoing esophageal/pancreatic surgery
- Present written consent

Exclusion Criteria

- Pregnancy
- Inclusion in another interventional study
- Refusal to participate in the study

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
- Do the different surgical techniques/wound surfaces in open vs. minimally invasive surgery in the esophagus and pancreas affect factor XIII activity?<br><br>- Do perioperative complications (bleeding complications, anastomotic insufficiencies and wound healing disorders) correlate with coagulation factor XIII activity?

Secondary Outcome Measures

Name	Time	Method
-Prevalence of FXIII deficiency?<br>-Perioperative course of FXIII levels?<br>-Correlation of factor XIII with transfusion requirements?<br>-Correlation of FXIII activity and duration of ventilation, length of intensive care stay and 28d mortality?