Citalopram vs Clomipramine vs Placebo in Recurrent Depression

Not Applicable

Completed

• Conditions: Depression
• Interventions: Drug: Citalopram; Drug: Clomipramine; Drug: placebo

• Registration Number: NCT01575158
• Lead Sponsor: University of Aarhus

Brief Summary

citalopram and clomipramine are better than placebo in preventing new episodes of depression in patients with recurrent depression

Detailed Description

Not available

Study Timeline

• Study Start: 1997-10
• Primary Completion: 2007-09
• Study Completion: 2007-09
• Status Verified: 2012-04
• Study First Submitted: 2012-04-10
• Study First Submitted QC: 2012-04-10
• Last Update Submitted: 2012-04-10
• Study First Posted: 2012-04-11
• Last Update Posted: 2012-04-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 59

Inclusion Criteria

• Patients with recurrent depression
• Sustained response achieved (3 consecutive monthly ratings at the HDS below 13)after a treatment requiring index episode

Exclusion Criteria

• Contraindications to study medications
• Pregnancy
• Substance abuse

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
citalopram	Citalopram	citalopram
clomipramnine	Clomipramine	clomipramine
placebo	placebo	placebo

Primary Outcome Measures

Name	Time	Method
2 Hamilton Depression Rating Scale scores of at least 16 with one weeks interval or initiation of another antidepressant treatment	2 years of follow-up

Secondary Outcome Measures

Name	Time	Method
Study termination due to adverse event or non-compliance	2 years of follow-up