Citalopram Versus Citalopram Plus Pindolol in Latency of Antidepressant Response Shortening in Major Depressive Disorder
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Scores on Hamilton Depression Rating Scale
研究概览
简要总结
The purpose of this study is to examine whether the speed of the clinical antidepressant action of citalopram can be accelerated by administering double doses of pindolol (15 mg/day, tid) which presumably should lead to increased 5-HT1A autoreceptor occupancy.
详细描述
Design, Settings, and Participants. A randomised, double-blind, placebo-controlled trial with MDD patients allocated to two treatment arms: citalopram + pindolol versus citalopram + placebo. Participants: outpatients with a depressive episode (DSM-IV criteria) were selected from a general hospital.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with a depressive episode
- •HDRS score > 18
- •Written informed consent
排除标准
- •suicidal risk > 3
- •severe organic illness
- •other psychotropic drugs
研究组 & 干预措施
Citalopram + placebo
Citalopram 20 mg/day t.i.d
干预措施: Pindolol (Drug)
Citalopram + pindolol
Citalopram 20 mg/day t.i.d Pindolol 15 mg/day t.i.d.
干预措施: Pindolol (Drug)
结局指标
主要结局
Scores on Hamilton Depression Rating Scale
时间窗: 8 time points through 6 weeks
次要结局
未报告次要终点