Effect of NO Precursors on Physiological Responses to Exercise

Not Applicable

Completed

• Conditions: Physiology

• Registration Number: NCT02850367
• Lead Sponsor: University Hospital, Grenoble

Brief Summary

NO is an ubiquitous molecule contributing to many physiological functions such as vasodilation, immune and oxidative stress responses. NO production can be supplemented either by providing substrate to the NO-synthase (L-Arginine and L-Citruline) or by providing nitrate which can lead to NO. In the present project the investigators evaluate the effect of various acute and chronic oral NO precursors supplementation on exercise performance and responses in healthy young and older subjects.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-05-09
• Study First Submitted: 2016-05-18
• Study First Submitted QC: 2016-07-26
• Study First Posted: 2016-08-01
• Status Verified: 2020-01
• Primary Completion: 2021-09
• Study Completion: 2021-09
• Last Update Submitted: 2021-09-28
• Last Update Posted: 2021-09-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 63

Inclusion Criteria

• Sedentary subjects
• No cardiovascular, respiratory, metabolic and neurological disorders

Exclusion Criteria

• Body mass index > 28 kg.m-2
• Smoker
• Alcool intake > 10g/day
• Psychiatric diseases
• Subjects under treatment able to interfere with their cardiovascular, metabolic and neurological status

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Neuromuscular evaluations	3 half days	After the intake of the supplement. Measure the stretching force in the ankle (N)
Evaluation of post-ischemic vascular reactivity	3 half days	After the intake of the supplement. Concentration of hemoglobin (g/mL) in the quadriceps with the device : NIRS system Oxymon, ARTINIS.

Trial Locations

Locations (1)

Grenoble University Hospital; 🇫🇷 Grenoble, Rhone Alpes, France