Prospective Study on Endothelial Function in Subjects With Type 2 Diabetes Mellitus
Overview
- Phase
- Not Applicable
- Intervention
- Telmisartan 80 mg/d
- Conditions
- Type 2 Diabetes Mellitus
- Sponsor
- University of Erlangen-Nürnberg Medical School
- Enrollment
- 69
- Locations
- 1
- Primary Endpoint
- Change in eGFR after 1 year
- Status
- Completed
- Last Updated
- 11 years ago
Overview
Brief Summary
Basal nitric oxide (NO) activity plays a pivotal role in the regulation of glomerular hemodynamics, and in animal experiments its alteration has been associated with morphological changes characteristic of diabetic nephropathy. The investigators aimed to assess in a prospective study: 1. basal NO activity of renal vasculature and 2. renal hemodynamics to examine whether impairment of basal NO activity of the renal vasculature is related to development and progression of diabetic nephropathy and other cardiovascular endpoints.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Type 2 Diabetes mellitus
Exclusion Criteria
- •Macroalbuminuria
- •Symptomatic cardiovascular disease
Arms & Interventions
A
Subjects with type 2 diabetes mellitus, eGFR \> 80, hypertension, no overt proteinuria
Intervention: Telmisartan 80 mg/d
B
Subjects with type 2 diabetes mellitus, eGFR \> 80, hypertension, no overt proteinuria
Intervention: Ramipril 10 mg/d
Outcomes
Primary Outcomes
Change in eGFR after 1 year