Renal Hemodynamics and Tubular Function in Patients With Obstructive Sleep Apnea and Healthy Controls

Phase 4

Completed

• Conditions: Obstructive Sleep Apnea; Healthy

• Registration Number: NCT00410085
• Lead Sponsor: Regional Hospital Holstebro

Brief Summary

Nitrogen-oxide (NO) plays an important role for blood pressure regulation, renal hemodynamics, and the renal excretion of sodium. NO is synthesized from L-arginine in the vascular endothelium and have a very short half-life in plasma and is therefore very difficult to measure directly.

L-mono-methyl-L-arginine (L-NMMA) is an analogue to L-arginine and a competitive inhibitor of NO, and therefore can be used to study the effect of NO on the circulation. In normal subjects, infusion of L-NMMA will cause an increase in blood pressure, decreased renal plasma-flow, decreased glomerular filtration rate, and a decreased excretion of sodium.

Hypothesis: Patients with obstructive sleep apnea has a decreased activity in the NO-system. This is contributing to the hypertension often seen in these patients. Decreased activity in the NO-system can be revealed by diminished fall in renal hemodynamic and sodium excretion after infusion of L-NMMA.

Detailed Description

Not available

Study Timeline

• Study Start: 2005-01
• Study Completion: 2005-11
• Study First Submitted: 2006-12-10
• Study First Submitted QC: 2006-12-11
• Study First Posted: 2006-12-12
• Status Verified: 2008-04
• Last Update Submitted: 2008-04-17
• Last Update Posted: 2008-04-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Obstructive sleep apnea

Exclusion Criteria

• Drug or alcohol abuse
• Pregnancy
• Disease of the heart, lungs, liver, kidney or endocrine organs
• Cerebral infarction
• Diabetes
• Gastrointestinal disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Trial Locations

Locations (1)

Department of Medical Research, Holstebro Hospital; 🇩🇰 Holstebro, Ringkoebing County, Denmark