Exercise-training Before Coronary Artery Bypass Graft (CABG)
Not Applicable
Completed
- Conditions
- AnginaCoronary Artery Disease
- Registration Number
- NCT00218985
- Lead Sponsor
- Norwegian University of Science and Technology
- Brief Summary
The aim is to evaluate the effect of exercise training upon endothelial function in the mammary artery of patients who are scheduled for CABG, as well as study the functional properties of single cells isolated from a small biopsy of the left ventricle obtained during surgery.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
- Scheduled for CABG both with and without heart failure
Exclusion Criteria
- Unstable angina
- Unable to walk on a treadmill (except those with heart failure who only will serve as a reference group)
- Participation in another study
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Cardiovascular function and quality of life Before and up to 1 year after intervention
- Secondary Outcome Measures
Name Time Method Cardiomyocyte structure and function after the intervention period Structure and function of cardiomyocytes After the intervention period
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie improved endothelial function in mammary artery following pre-CABG exercise training?
How does preoperative exercise training compare to standard pre-CABG care in improving cardiovascular outcomes?
Are there specific biomarkers that predict enhanced left ventricular function post-exercise training in CABG patients?
What are the potential adverse events associated with pre-CABG exercise protocols and how are they managed?
What combination therapies or pharmaceutical agents synergize with preoperative exercise to optimize CABG outcomes?
Trial Locations
- Locations (1)
Norwegian University of Science and Technology
🇳🇴Trondheim, Norway
Norwegian University of Science and Technology🇳🇴Trondheim, Norway