Pituitary dysfunction after traumatic brain injury: a new challenge in neurotraumatology - Pituitary dysfunction after traumatic brain injury

niversitair Medisch Centrum Sint Radboud0 sites600 target enrollmentTBD

Overview

No summary available.

Registry

who.int

Start Date

TBD

End Date

TBD

Last Updated

last year

Study Type

Observational invasive

Sponsor

niversitair Medisch Centrum Sint Radboud

•1\. All patients who visit the emergency department with a mild, a moderate or a severe traumatic brain injury. (Mild traumatic brain injury is defined as a history of impact to the head and a Glasgow Coma Scale score (GCS) 13\-15 at entry in the emergency room, moderate traumatic brain injury is defined as a GCS 9\-12 at entry in the emergency room, and severe traumatic brain injury is defined as a GCS \<\= 8 at entry in the emergency room)
•2\. Initial trauma occurred less than 24 hours before visiting the Emergency Department.
•3\. Age \>\= 18 years and \<\= 65 years

•1\. Age \> 65 years or \< 18 years
•2\. No oral or written informed consent by patient or proxy
•3\. Pre\-existent neuro\-endocrine disorder
•4\. Instable infiltrative disease in the hypothalamus/pituitary region (eg sarcoidosis, tumour metastasis)
•5\. BMI \>30 kg/m2
•6\. Pregnancy or wish for pregnancy during the study period women, lactation
•7\. Co\-existent disease with decreased life expectancy, especially active malignant tumor
•8\. Chronic alcohol or drug abuse