The effect of zinc supplements on the oxidative stress and reduction of withdrawal symptoms in opioid addicts in the withdrawal syndrome

Phase 3

Recruiting

Conditions: People with Opioid Addiction.
Family history of other substance abuse
Z.81-4

Registration Number: IRCT20190811044513N1

Lead Sponsor: Hamedan University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 40

Inclusion Criteria

Opioid use for two years and more
Admission within a maximum of one week from the time of withdrawal
Not taking medications away from the specialist opinion
Absence of acute and chronic inflammatory diseases and any other acute or chronic infections
Lack of AIDS, hepatitis and diabetes

Exclusion Criteria

Re-consuming by people before sampling
Use of drugs that have an effect on inflammation and oxidative stress
Getting any disease during research
Attempted suicide or a history of it during the past year

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Oxidative stress factors, reduction of withdrawal symptoms. Timepoint: At the beginning and end of the study. Method of measurement: Serum level measurement by using kits.

Secondary Outcome Measures

Name	Time	Method
Antioxidant capacity of serum. Timepoint: At the beginning and end of the study. Method of measurement: Colorimetric method.;Lipid Peroxidation Index. Timepoint: At the beginning and end of the study. Method of measurement: Colorimetric method.;Thiol groups index. Timepoint: At the beginning and end of the study. Method of measurement: Colorimetric method.;Enzymatic activity of glutathione peroxidase. Timepoint: At the beginning and end of the study. Method of measurement: Colorimetric method.;Enzymatic activity of superoxide dismutase. Timepoint: At the beginning and end of the study. Method of measurement: Colorimetric method.;Evaluation of withdrawal symptoms. Timepoint: At the beginning and end of the study. Method of measurement: COWS questionnaire.